Global Journal of Pharmacy & Pharmaceutical Sciences

Quorum Sensing by Super Bugs and their Resistance to Antibiotics, a Short Review

Author: Jayita Goswami*

Published: August 02, 2017

DOI: 10.19080/GJPPS.2017.03.555614

Abstract Content: Bacteria’s are the primitive form of the organisms that evolved millions of years ago and still, exist in our society. Like other animals, bacteria’s have the power of sensing or adaptation. It can detect odd, harsh environment and survive accordingly. Quorum sensing is a well-known field that scientists have explored for long years. Bacteria’s flagella can touch and sense odd molecules and escape the harsh living areas. In the adverse situation, they produce spores to survive from drought or any other natural calamities. The cell membrane is a unique part of a bacterial body that protects the nucleic acid from destruction. The nucleic acid is pH sensitive, temperature sensitive and it degrades when cell wall or membrane is absent. Like plants, bacteria also have pores in their membranes. Through these pores, they exchange gas, ions and nutrients and genetic materials. In the adverse situation, they close most of the pores and keep one or two pores open to gather nutrients or to transfer genetic materials. This is how they developed horizontal gene transfer mechanism. Cell fusion is the basic idea of horizontal gene transfer. This is also called asexual reproduction. Bacteria’s developed resistance against quorum quencher molecules too. The mobile genes or the genes in plasmid those are associated with sensory organelles like flagella helps bacteria to develop resistance against molecules. Natural and artificial chemicals have used against quorum sensing and people found success with it.