Open Access Journal of Toxicology

The Importance of Dose-Time-Response Relationships for Hazard Identification and Limitation of Animal Experiments

Author: Henk A Tennekes

Published: August 22, 2017

DOI: 10.19080/OAJT.2017.01.555572

Abstract Content: Historian Heiko Stoff has recently sketched a fascinating controversy in the 1950’s on chemical risk assessment [1]. Two renowned scientists in the Farbstoffkommission (Dye Committee) of the Deutsche Forschungsgemeinschaft (DFG, German Research Community), pharmacologist Hermann Druckrey and biochemist (and Nobel Prize winner) Adolf Butenandt, were advocates of a preventive risk approach. This approach was largely determined by a groundbreaking study conducted by Druckrey during the war years with the carcinogenic dye 4-dimethylaminoazobenzene (also known as “butter yellow”) [2], and Druckrey’s un-intentional cooperation with the electrophysicist Karl Küpfmüller in an American detention camp in Hammelburg, Bavaria [3].