Duong Nguyen Thi Thuy; Thao Mai Phuong

doi:10.19080/OFOAJ.2019.11.555810

Mini Review

Marine Microbial Bioactive Compounds: New Way to Treat Resistance of Neglected Tropical Diseases

Duong Nguyen Thi Thuy* and Thao Mai Phuong

VN-UK Institute for Research and Executive Education, The University of Danang, Vietnam

Submission:November 04, 2019; Published:December 03, 2019

*Correspondence author: Duong Nguyen Thi Thuy, VN-UK Institute for Research and Executive Education, The University of Danang, Vietnam

How to cite this article:Duong Nguyen Thi Thuy, Thao Mai Phuong. Marine Microbial Bioactive Compounds: New Way to Treat Resistance of Neglected Tropical Diseases. Oceanogr Fish Open Access J. 2019; 11(2): 555810. DOI: 10.19080/OFOAJ.2019.11.555810

Mini Review

The neglected tropical diseases (NTDs) are most prevalent in cause severe and lifelong impairment in the world. Causing of these infectious diseases belongs to several pathogenesis groups, including vector-borne protozoa, bacteria and two species of non-tuberculosis mycobacteria. Despite causing serious complications, NTDs has been rarely concerned because the majority of cases occur in underdeveloped countries, whose health care standards are only acceptable to poor [1]. Nevertheless, recent studies have highlighted major technology hubs even markedly increased susceptibility to NTDs because natural population growth and over longstanding rural-urban migration. So far, NTDs matter in large modern cities in Japan, China, Singapore, Taiwan, which have been stayed in vague state and weakly control in diagnosis and treatment [2]. In addition, it has been indicated that these diseases can also drive patients get both serious physical and psychosocial damage during their long lived-life [3].

Efforts in isolation and preventing infectious diseases are more difficult than ever before under an international spread of multidrug resistance in bacteria. Notably, Salmonella species as a pathogenesis organism of various infections in patients that is a significant cause of morbidity and mortality worldwide. Not only does the burden on the food industry, but it also leads to several co-morbidities, such as HIV infection, malaria, and malnutrition [1,4]. It has been estimated that there are approximately 20-25% of case fatality in blood stream infection in African adults and children. Non-typhoidal Salmonella disease include respiratory symptoms, fever, and hepatosplenomegaly. Moreover, S. Typhimurium ST313 which has emerged in sub-Saharan Africa is predominantly becoming a multidrug resistance factor in the health services around the world [5].

Basically, antimicrobial chemotherapy commonly used in the treatment patient with bacterial infections. Extended-spectrum antimicrobials like chloramphenicol, trimethoprim-sulfamethoxazole were recently shown to have efficacy generally for many infected Salmonella sp. cases. Unfortunately, microbes

To access new sources of anti-infective drugs, natural products (NPs), it has been proven that the marine environment is a rich origin with considerable antimicrobial compounds like anti-fungal, anti-parasitic, anti-bacterial, anti-virus medicines. According to the stream of using NPs, the discoveries of marine’s metabolite products have remarkably increased in quantity and quality [8]. A recent design of marine fungi Penicillium sp-derived compounds show its possession through invaluable actions against microbe’s ability to persist, multiply, and produce virulence [9]. Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities [10]. Butanolides are a class of lactones with a four-carbon heterocyclic ring structure is now show the ability of anti-macrofouling compound, which has been found marine Streptomyces sp. resin. They are not only effective prevent the biofilm formation, but also eliminated pre-formed biofilms of testing model [11]. The purification with thin-layer chromatography of Phomopsis sp. XP-8 broth showed significant inhibition on multi-drug resistance of foodborne pathogens [12]. The data showed marine metabolites contain useful bioactive compounds that can be used to prevent bacterial actions [13]. Hence, marine metabolites need to be evaluated, considered andresearched more as one of the most essential sources regarding potential products in research, which can bring their power from bench to bedside.