The Treatment of Diabetic Retinopathy and Other Retinal Disorders Via Optic Orr- A Topical Innovation
Vinod C Tawar*
Family physician and a clinical researcher, king george medical center, Canada
Submission:March 15, 2019; Published: May 23, 2019
*Corresponding author:Vinod C Tawar, Family physician and a clinical researcher, King George medical center, surrey, b.c. Canada
How to cite this article:Vinod C Tawar. The Treatment of Diabetic Retinopathy and Other Retinal Disorders Via Optic Orr- A Topical Innovation. JOJ
uro & nephron. 2019; 6(4): 555694. DOI: 10.19080/JOJUN.2019.06.555694
Disorders associated with diabetes commonly include a decreased vision to blindness and cataract formation. A focus of this study was to determine a beneficial role of vitamin A applied through the principle of transdermal absorption . The objective was to avoid having systemic adverse effects. The duration of treatments was found to be optimal for 12-16 weeks. The concept of employing vitamin a was derived from a known significant role of vitamin a in visual functions in humans. The cream based topical formulation was named optic Orr (vision correction). 27 subjects were studied of both genders for a duration of 12-16 weeks and periodically visual acuity was assessed by using Snellen charts in the office or symptoms evaluations, in cases of patients with retinal injuries. The result was patients showing increased visual acuity mainly in daytime vision (cone regeneration).
The approach of this research was inspired by several researches conducted earlier as described below. Chowers et. al  in 2001 had demonstrated regeneration of retina with oral doses of vitamin A. Owseley  and his colleagues in 2006 had established a beneficial effect of a high (oral) dose of retinol in ageing and age-related maculopathy. Mactier  and his group in 2012 had proven an improvement of retinal functions in infants by vitamin A supplementation orally. Berson et.al.  In 2012 had assessed the visual acuity increases in patients with retinitis pigmentosa receiving vitamin A. Shaberman  and his collaboratos in 2015 termed vitamin A as a fuel for vision. Kiser PD & Palczewski  had proven an association between retinoids and their impact on retinal diseases. Liu  and his colleagues stressed the useful role of retinoids in the same illness. She  and his associates in 2017 stressed the association between carotenoids and a risk of diabetic retinopathy in vitamin A deficient case. Hussain RM  and his collegues in 2018 had studied pharmacotherapy of retinal diseases with visual cycle modulators. sella et al. . In January 2019 had established a link between vitamin A,C,D,E and K deficiency and cataract formation. In March 2019 Aghalia E  and his collegues investigated vitamin a supplementation in Nigeria in relation to childhood blindness.
A primary objective was to target patients with a history of diabetes . However, a few select cases were encountered with episodes of retinal detachment resulting in severely diminished vision or retinal injuries.
Vitamin A in the form of retinyl palmitate was weighed to render a concentration as permitted by health Canada. In addition, various essential oils were added and incorporated into a lip balm base at a warmer temperature to provide a homogeneous mixture . Samples weighing 12 grams. Each were given to patients on trial and they were seen in a follow-up every 4 weeks. The mode of administration was applying the opticorr cream twice a day externally on upper and lower eye lids.
Visual acuity changes were determined by Snellen chart and in cases of retinal injuries ophthalmological consultation was done. Results of the study are described in the enclosed table. The parameters of study considered are age of the patient, duration of diabetes the patient has endured and resolution of symptoms ( time required of treatment to see improvements in visual
acuity to a near normal level) . A duration of treatment needed
for a satisfactory improvement may have been dependent on the
level of glycemic control i.e. Sub-optimal control would reflect
a longer need of treatment. In addition, rg represents patients
with retinal injuries or glaucoma and rc includes a patient with
retinitis and corneal injuries.
Optic Orr application was found to be free of any sideeffects.
In rare cases one may exhibit hypersensitivity by having
erythema in peri-orbital region and or burning sensation.
Patients were advised to discontinue using the product in those
cases. However, hypersensitivity was of a rare occurrence. As
described earlier the extent of treatment needed were variable.
Most of the study participants demonstrated visual improvement
to a near normal level in 3 to 4 months.
i. A 75 yrs. Old male with a history of retinal detachment
7 years earlier and resulting blindness, in spite of 4
surgeries, had seen a normal day time vision after a 4 months
application of optic Orr.
ii. A 57 years old female was diagnosed with retinal injury
causing diminished vision and was scheduled for a surgery.
She had a full recovery after 12 weeks of using the cream and
was informed of not requiring the surgery at the end since
the injury had healed.
iii. A 70 years old male had a one-week history of
diminishing vision from an acute retinal injury in one of his
eyes and had experienced full relief of symptoms after using
the cream for next 2 weeks.
Optic Orr is currently under a patent protection. It was
initially formulated for the treatment of various forms of
dermatitis (resistant to oral treatments). Antiwrinkle effects and
currently recognized for glaucoma , adult macular degeneration
and cataracts prevention. Our current projects are focussed on
evaluating these benefits. Our recent clinical observations have
been in the beneficial role of vitamin a as an immunity mediator
and in cases of inflammation . Further studies by Esposito
and his colleagues had recognized wound healing effects of
retinyl palmitate  and further recognition of vitamin a in the
enhancement of immune function by Huang et al. .