A Science Opinion on Polyscias Fruticosa And Morus Alba L. Combination: Better Anti-Diabetic and Late Complication Inhibitory Properties?
Quang-Ung Le1*, Horng-Liang Lay2 and Thi-Thu Le3
1Department of Tropical Agriculture and international Cooperation, National Pingtung University of Science and Technology, Taiwan
2 Department of Plant Industry, National Pingtung University of Science and Technology, Taiwan
3Agri-Forestry Technology Department, Thai Nguyen Economy and Technology College, Vietnam
Submission: April 17, 2019; Published: May 17, 2019
*Corresponding author: Quang-Ung Le, Department of Tropical Agriculture and international Cooperation, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan
How to cite this article: Quang-Ung Le, Horng-Liang Lay, Thi-Thu Le. A Science Opinion on Polyscias Fruticosa And Morus Alba L. Combination: Better Anti-Diabetic and Late Complication Inhibitory Properties?. Curre Res Diabetes & Obes J. 2019; 10(5): 555798. DOI: 10.19080/CRDOJ.2019.10.555798
Abstract
Based on our knowledge and field survey results in control and management of diabetes mellitus by complementary/alternative medicine and especially the consumption of herbs, we briefly commented on anti-diabetic properties of Polyscias fruticosa and Morus alba L. combination.
Keywords:Polyscias fruticosa; Morus alba L; Diabetes mellitus; Alternative medicine; Complementary medicine; Anti-diabetic properties; Herbs; Western medicine; Blood circulation; Hyperglycemia; Diabetic retinopathy; Lipids
Introduction
Traditional Vietnamese medicine (TVM) is a type of popular alternative medicine applied to treat diseases as well as improve general well beings. Many herbs have attracted substantial attention because they have beneficial efficacy more than western medicine. Interestingly for patients with diabetes mellitus, consumption of both Polycias fruticosa and Morus alba L is claimed to be beneficial.
According to TVM theory, the development of diabetes mellitus is associated with deficiency of both energy and body fluids and results in the heat of tissues and blood or urine stasis (congested blood circulation or urine) [1]. The late complications of diabetes include a series of clinical pathologies, mainly related to the involvement of the arterial wall both of large vessels and small vessels, and of the peripheral nervous system. The metabolic abnormalities due to hyperglycemia lead to the development of late diabetic complications which related coherently genetic background, such as diabetic retinopathy, renal failure and diabetic neuropathy, cardiomyopathy (heart failure) observed in these patients [2]. Furthermore, it is believed that these two herbs could combine synergistically with each other, which enhanced anti-diabetic efficacy and inhibit late diabetic complications. In order to provide scientific evidences to these opinions, the anti-diabetic effects of Morus alba L and practical application of Polyscias fruticosa have been reported and interviewed.
Mulberry (Morus alba L.) leaf has been known to have hypoglycemic effects since ancient times. In Vietnam and Asia countries, mulberry leaf is consumed as tea for the treatment of diabetes mellitus. Thirty-day treatment with mulberry powder exhibited significantly lower fasting blood glucose compared to glibenclamide [3]. The treatment with mulberry tea can cause malabsorption of carbohydrates [4,5]. Results of a clinical trial that combined dietary control, exercise, and the total alkali fraction from mulberry leaf showed a reduction of blood glucose, regulation of lipids and fewer side effects compared with acarbose treatment [6]. Mulberry tea has also been shown to suppress postprandial hyperglycemia after 90 min of its consumption [7].
Polyscias fruticosa belonging Araliaceae family is used as a tonic and medicinal food in traditional medicine because this herb possesses wondrous health benefits. Consuming it for long time help to enhance and improve physical body. Other benefits such as anti-anxiety, restoration of brain circulation function and improvement of nervous system function also were observed. Although there has no science evidence that Polyscias fruticosa have anti-diabetic benefits, practical applications reveal this. Moreover, it might contribute to properties of late complication inhibitory.
The survey results showed that recently, in Vietnam diabetic patients consuming combination of two these herbs themselves showed synergistic relationship for all diabetic properties over the range of doses under investigation. The most promising antidiabetic property of Polycias fruticosa and Morus alba L is their inhibitory capacity of late complications of diabetes. Additionally, when the herbs were used together, strong synergistic effect was stated by diabetic patients.
The survey results showed that recently, in Vietnam diabetic patients consuming combination of two these herbs themselves showed synergistic relationship for all diabetic properties over the range of doses under investigation. The most promising antidiabetic property of Polycias fruticosa and Morus alba L is their inhibitory capacity of late complications of diabetes. Additionally, when the herbs were used together, strong synergistic effect was stated by diabetic patients.
References
- Li YJ, Xu HX (2009) Research progress on anti-diabetic Chinese Medicines. Zhong Yao Cai 29(6): 621-625.
- Squadrito G, Cucinotta D (1991) The late complications of diabetes mellitus. Ann Ital Med Int 6(1): 126-136.
- Andallu, B, Suryakantham V (2001) Effect of mulberry (Morus indica) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clinica Chimica Acta 314(1-2): 47-53.
- Zhong L, Furne JK (2006) An extract of black, green, and mulberry teas causes malabsorption of carbohydrate but not of triacylglycerol in healthy volunteers. Am J Clin Nutr 84(3): 551-555.
- Mudra M, Ercan-Fang N (2007) Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75g sucrose by type 2 diabetic and control subjects. Diabetes Care 30(5): 1272-1274.
- Liu Q, Liu J (2013) The treatments of total alkali from Morus folium jiangtang capsule combined with diet and exercise program for type 2 diabetes mellitus equivalence randomized controlled study. Journal of Practical Traditional Chinese Internal Medicine 27: 24-27.
- Banu S, Jabir NR (2015) Reduction of post-prandial hyperglycemia by mulberry tea in type-2 diabetes patients. Saudi J Biol Sci 22(1): 32-36.