Comparison of Teneligliptin and Atorvastatin on Lipid Profile in Patients with Type 2 Diabetes Mellitus
V Vyshnavi1, T Supriya1, Bandaru Siva Subrahmanyam2, Eggadi Venkateshwarlu, Bandaru Sheshagiri and Sharvana Bhava1
1Department of Clinical Pharmacy, Vaagdevi College of Pharmacy, Warangal, Telangana, India
2Sri Bhadrakali Diabetic Clinic, Naimnagar, Hanamkonda, Warangal, Telangana, India
Submission: March 27, 2018; Published: August 08, 2018
*Corresponding author: Eggadi Venkateshwarlu, Bandaru Sheshagiri Sharvana Bhava, Department of Clinical Pharmacy, Vaagdevi College of Pharmacy, Warangal, India, Email: sharavanabhava6@gmail.com
How to cite this article: V Vyshnavi, T Supriya, Bandaru Siva Subrahmanyam, Eggadi Venkateshwarlu Bandaru Sheshagiri Sharvana Bhava. Comparison of Teneligliptin and Atorvastatin on Lipid Profile in Patients with Type 2 Diabetes Mellitus. Curre Res Diabetes & Obes J. 2018; 8(2): 555735. DOI: 10.19080/CRDOJ.2018.08.555735.
Abstract
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both which results in long term damage, dysfunction and failure of various organs especially eyes, kidneys, nerves, heart and blood vessels. The efficacy of Teneligliptin and Atorvastatin on lipid profiles in patients with type 2 Diabetes mellitus were compared. This study was designed to evaluate the efficacy of these two drug regimens.
Material and methods:Males and females of 25-90 years diagnosed with type 2 Diabetes mellitus are included in our study.
Results:275 patients were recruited for our study. 47 were excluded because of their inability to attend or participate and did not meet inclusion criteria. 229 T2 DM patients who were taking Teneligliptin 20mg once daily or Atorvastatin 20mg once daily completed the study. There were significant decrease in the levels of TC, HDL, LDL, TG, VLDL in Teneligliptin and Atorvastatin are 35.1, 4.1, 14.8, 37, 7.5(mg/dl) and 35.1, 4, 14.6, 37.1, 7.6(mg/dl) respectively
Conclusion:From this study we conclude that Teneligliptin 20mg and Atorvastatin 20mg have proved to have similar efficacy on the lipid profiles. Hence we conclude that Teneligliptin is an efficacious drug for T2 DM patients in management of glycemic control and lowering lipid profiles.
Background and Aim
Diabetes mellitus is a group of metabolic diseases which challenges the global population. Thus, there is an increasing need to conduct research in this field [1,2]. The aim of the study is to compare the efficacy of Teneligliptin and Atorvastatin on lipid profile of patients with T2 DM. Comparative evidence is required to guide appropriate therapy to attain lipid control and prevent complications of diabetes [3,4].
Material and Methods
It is a prospective, observational, comparative study conducted in patients from “Sri Bhadrakali Diabetic Clinic” located at Naimnagar, Hanamkonda. Patients were explained about the study & informed consent forms were seeked by explaining them in their local language [5,6]. Institutional Human Ethical Committee Endorsement was obtained after submission of protocol and IHEC No. is MGM/VCOP/PHARMD/V/017/2017.
Inclusion criteria
Males and females of 25-90 years diagnosed with type 2 Diabetes mellitus will be included in our study
Exclusion criteria
Pregnant and lactating females, patients on insulin therapy, history of type1 Diabetes mellitus, signs of diabetic complications (neuropathy, nephropathy and retinopathy) are to be excluded [7]. Patients with clinical signs and symptoms of acute myocardial infarction, liver failure, chronic heart failure, and hypertension are to be excluded.
Study design
It is a prospective, observational, comparative study design, and the patients who were taking Teneligliptin 20mg and Atorvastatin 20mg were included [8].
Clinical response assessment
The efficacy of Teneligliptin and Atorvastatin was assessed by measuring the change in the HbA1c, Fasting blood glucose, Post prandial blood glucose and Lipid profile levels after 12 weeks of treatment.
Primary end was change in HbA1c levels, FBS, PLBS levels at 12 weeks as compared to the baseline levels in both the groups [9].
The secondary end point was change in lipid profile levels such as serum cholesterol, high density lipoproteins, low density lipoprotein, triglycerides and very low-density lipoprotein which were measured at 12 weeks as compared to baseline levels [10].
Statistical analysis
All parameters were expressed as mean±SD. Data analyses was performed using the GRAPH PAD PRISM 5.0. One way ANNOVA was used to assess significant differences between values obtained before and 3 months after the addition of Atorvastatin and Teneligliptin (Figure 1).

Results
High density lipoproteins (Figure 2)
Mean change in high density lipoprotein for Teneligliptin was 39.3±14.4mg/dl.
Mean change in high density lipoprotein for Atorvastatin was 39.3±34.8mg/dl.

Total cholesterol (Figure 3)
Mean change in total cholesterol for Teneligliptin was 172.6±80.5mg/dl.
Mean change in total cholesterol for Atorvastatin was 172.7±86.5mg/dl.

Low density lipoproteins (Figure 4)
Mean change in low density lipoprotein for Teneligliptin was 97.1±33mg/dl.
Mean change in low density lipoprotein for Atorvastatin was 97±36mg/dl.

Triglycerides (Figure 5)
Mean change in triglycerides for Teneligliptin was 169.4±83.8mg/dl.
Mean change in triglycerides for Atorvastatin was 169.5±67.4mg/dl.

Antifungal resistance
Mean change in low density lipoprotein for Teneligliptin was 33.4±13.2mg/dl.
Mean change in low density lipoprotein for Atorvastatin was 33.5±11.9mg/dl.

Discussion
Comparison of Teneligliptin 20mg and Atorvastatin 20mg was done on lipid profile of patients with T2 Diabetes mellitus. The following changes in glycemic parameters like HbA1c, FBS, PLBS and lipid profile (TC, HDL, LDL, TG, VLDL) were observed. In this study, Teneligliptin or Atorvastatin therapy from baseline to visit3 has provided a greater reduction in HbA1c i.e., Teneligliptin (1%) and Atorvastatin (1.5%). In the study [7], a similar decrease in HbA1c of 0.57% were observed. The mean changes in FBS levels from baseline to visit 3 was observed to be 45.8mg/dl in Teneligliptin and 45.6mg/dl in Atorvastatin. In the randomized, double blind study (n=99) by [8], Teneligliptin 20mg has showed greater reductions in the values of FBS-20.7mg/dl and 6.9mg/dl. Comparison of Teneligliptin 20mg and Atorvastatin 20mg were done on lipid profile of patients with T2 Diabetes mellitus.
Conclusion
From this study we conclude that Teneligliptin 20mg and Atorvastatin 20mg have proved to have similar efficacy on the lipid profiles. Hence, we conclude that Teneligliptin is an efficacious drug for T2 DM patients in management of glycemic control and lowering lipid profiles.
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