Author: Joachim Greilberger, Michaela Greilberger And Ralf Herwig*
Published: May 21, 2018
DOI: 10.19080/CTBEB.2018.14.55589 1
Abstract Content: Aim: Oxidative Stress May Play A Role In The Development And Clinical Manifestations Of Autism. Children With Autism Are More Vulnerable To Oxidative Stress In The Form Of Increased Lipid Peroxidation. Vitamin D Supplementation Is Known To Decrease Oxidative Stress By Ist Anti- Inflammantary Properties. Methods: Autistic Children (n=12) Were Administerd For Five Weeks Complexed Cholecalciferol-dimer (ImmunoD®) Orally Twice A Week. Before And After Five Weeks Supplementation Of Complexed Cholecalciferol Plasma Samples From Ten Autistic Children Were Collected And Lipid Peroxidation Markers Hydroxyalkenales (HAE), Malondialdehyde (MDA) And Lipid Peroxides Were Measured. Additionally, The Standardized University Of Cambridge AQ-10 Questionaire (AQ-10) In Its Original And Slightly Modified Version To Test For Changes In Behavior. Results: After Supplementation With Complexed Vitamin D HAE Decreased Significantly From 1.99±0.61μM To 1.09±0.65μM (p<0.02) And MDA Significantly From 0.99±0.48μM To 0.33±0.18μM (p<0.01) In The Autistic Children. The Content Of Lipid Peroxides In Autistic Children Were Also Reduced Significantly From 235.8±136.9μM To115.2±64.8μM (p<0.02). The Behavior Of The Probants Improved Significantly, Which Is Expressed By The Original And Modified Version Of The AQ-10 (p=0.001). In 6 Out Of 12 Of The Cases, An ASD Diagnosis Would Not Be Further Considered According To The Test Results. Furthermore, Significant Changes In Various Questions Could Be Observed, Demonstrating An Improvement In Relevant Facets Of Social Behavior. Conclusion: Supplementation Of Complexed Vitamin D Dimer Is Suggested To Decrease Oxidative Stress And Inflammation In Autistic Children And May Improve Their Social Behavior.
November 09, 2021
by Yoshiyuki Sasano*
Pages: 5
» moreOctober 06, 2020
by Jonathan E Aviv
Pages: 6
» moreAugust 07, 2020
by Sandra De Sousa Xavier*
Pages: 14
» more