Author: Masao Sugamata
Published: October 25, 2017
DOI: 10.19080/CTOIJ.2017.07.555718
Abstract Content: The Prevention Of The Malignant Tumor Is Thought To Be Early Detection, Because The Mechanism That Tumor Cells Result, And Progresses Has Not Been Yet Made Clear. We Have Already Identified Leukotriene Receptor Expression And Mast Cells Infiltration; These Are Common Pathologic Findings In Various Malignant Tumors. In This Time, We Detected A Similar Common Pathologic Finding For Polyp Of Colon Suggestive Of The Precancerous Change In The Purpose Of Preventing Malignant Tumor And Examined A Malignant Transformation Risk And The Association Of These Findings. Thirty Samples Of Colorectal Adenoma (colonic Polyp) Tissues Obtained From Patients With High-grade Dysplasia (n=15) Or Low-grade Dysplasia (n=15). These Samples Were Observed Mast Cells And Detected Of Leukotriene Receptors Under A Light Microscope, And Were Compared Using Statistical Analysis. Mast Cells Infiltration And The Expression Of Leukotriene Receptor Were Common In The Colonic Polyp Tissues And, Similar To Malignant Tumors, Were Found. The Tendency With Difference Had These Findings Between Histopathology Classifications. Especially, The Number Of Mast Cells Was Significantly Greater Within High-grade Than Within Low-grade (P < 0.0001). From These Results, The Possibility That Mast Cells And Leukotriene Receptor Were Associated With The Transitional Mechanisms From Benign Tumor To Malignant Tumor Was Shown. The Chronic Hypersensitivity Through Leukotriene Was Thought To Have Influence On The Malignant Transformation Of Colonic Polyps. Leukotriene Receptor Antagonist May Have High Effect Of Malignant Transformation Prevention In Colonic Polyps.
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