The Importance Of Dose-Time-Response Relationships For Hazard Identification And Limitation Of Animal Experiments

Author: Henk A Tennekes

Published: August 22, 2017

DOI: 10.19080/OAJT.2017.01.555572

Abstract Content: Historian Heiko Stoff Has Recently Sketched A Fascinating Controversy In The 1950’s On Chemical Risk Assessment [1]. Two Renowned Scientists In The Farbstoffkommission (Dye Committee) Of The Deutsche Forschungsgemeinschaft (DFG, German Research Community), Pharmacologist Hermann Druckrey And Biochemist (and Nobel Prize Winner) Adolf Butenandt, Were Advocates Of A Preventive Risk Approach. This Approach Was Largely Determined By A Groundbreaking Study Conducted By Druckrey During The War Years With The Carcinogenic Dye 4-dimethylaminoazobenzene (also Known As “butter Yellow”) [2], And Druckrey’s Un-intentional Cooperation With The Electrophysicist Karl Küpfmüller In An American Detention Camp In Hammelburg, Bavaria [3].