Abstract
Keywords: Takotsubo; HCM; Concurring; Overlap
Case Report
An 84 -year-old female with past medical history of atrial fibrillation, hypertension, diabetes mellitus, giant cell arteritis and depression, presented to the ER with chest pain. Electrocardiogram showed ST depression in leads I, AVL and V1-V6; serum Troponin I levels on admission were found to be elevated (1042 ng/l). Emergency cardiac catheterization showed unobstructed coronary lesions, but apical ballooning was demonstrated on ventriculography (Panel). Echocardiography confirmed near-akinesis and ballooning of the mid and apical segments with a reduced left ventricular ejection fraction of 35% (Panel). These findings were suggestive of Takotsubo (TTS).
Twelve days later a Cardiac Magnetic Resonance (CMR) showed complete resolution of apical ballooning, supranormal LVEF, with small size ventricles, asymmetrical hypertrophy of the interventricular septum and all apical segments (maximal thickness 16 mm), and associated intracavitary end systolic obliteration. On late enhancement images, there was patchy mid- wall enhancement detected in the mid and apical segments. Papillary muscles were apically displaced. These findings were typical of Hypertrophic Cardiomyopathy (HCM) (Figure 1).
TTS is an acquired condition most commonly affecting postmenopausal women who suffer a severe psychological or physical stressor. Concurring TTS and HCM presents mainly in females, with only half of them having being previously outlined with a known history of HCM. Although the approach to treat either condition separately is common practice, the simultaneous management of both entities in the acute phase poses a clinical challenge and relies on close monitoring and balancing of their opposing haemodynamic profiling.
