Journal of Cardiology & Cardiovascular Therapy

Case Report

Eosinophilic Heart Disease: A Case Report and Review of Literature

Ghulam Akbar*, Fnu Vikram, Ronald Freudenberger and Matthew Martinez

Department of Cardiovascular Medicine, Lehigh Valley Hospital Cedar Crest, USA

Submission: March 08, 2017; Published: March 30, 2017

*Corresponding author: Ghulam Akbar, Department of Cardiovascular Medicine, Lehigh Valley Health Network, 1250 S Cedar Crest Blvd, Lehigh Valley Hospital, Allentown, PA 18103, Email:ghulam.akbar@lvhn.org

How to cite this article: Ghulam A, Fnu V, Ronald F, Matthew M. Eosinophilic Heart Disease: A Case Report and Review of Literature. J Cardiol & Cardiovasc Ther 2017; 4(2): 555631. DOI:10.19080/JOCCT.2017.04.555631

Introduction

Hypereosinophilic syndrome (HES) is a multisystem disorder diagnosed by the presence of hypereosinophilia (HE) defined as an absolute eosinophil count (AEC) >1.5x109/L (or >1500cells/microL) and multi organ involvement attributable to HE. Myocardial dysfunction is a frequent finding and is a major cause of morbidity and mortality in HES. The diagnosis of hypereosinophilic heart disease (EHD) is made in the setting of hypereosinophilia and characteristic clinical features and imaging findings of damage to the heart. We describe those clinical features in this case of HES with HHD with review of literature.

Case Report

A 63 year old male with no known past medical history was transferred to our hospital for hypotension, abnormal EKG and elevated troponin. The patient described nonspecific symptoms of cough, runny nose, malaise, muscle aches, nausea, diarrhea and low grade fever for 2-3 weeks. He also noted a skin rash which had resolved at the time of admission. He denied air travel outside the United States, no prior known malignancies or inflammatory diseases such as vasculitis or autoimmune diseases. He has no history of diabetes mellitus, hypertension or hyperlipidemia but is an active smoker. His examination revealed diminished lung sounds bilaterally, normal heart sounds with a soft 1/6 intensity holosystolic murmur without marked radiation of the murmur. There was mild lower extremity edema present. His electrocardiogram showed sinus rhythm with diffuse T-wave inversions. He had a contrast enhanced CT of his chest abdomen and pelvis which revealed no pulmonary embolism or dissection, marked lymphadenopathy and small pleural effusions only. His pertinent laboratory data revealed hyponatremia, normal creatinine and an elevated troponin I value of 2.89. He was found to have an elevated white blood cell count of 15000, hemoglobin 9 gram/dl and platelet count of 40,000. His eosinophil count was 4800 (UNITS). A transthoracic echocardiogram revealed hyperdynamic left ventricular (LV) systolic function and apical thickening concerning for an LV thrombus (Figure 1a & 1b). An MRI of the heart confirmed the diagnosis of apical thrombus along with fibrotic material seen in both LV and RV apex (Figure 2a & 2b). In the presence of hypereosinophilia and the imaging findings a diagnosis of HES was made. He was initiated on anticoagulation.

Discussion

HES are a heterogeneous group of disorders. Typically symptoms are very nonspecific as in our case. A rash, GI disturbances, cough and dyspnea are the common symptoms. Myocardial involvement in HES was first described in 1936 by Wilhelm Loffler who reported a ‘fibroplastic parietal endocarditis with blood eosinophilia’ [1]. Prevalence of EHD in HES is up to 50% [2,3]. Myocardial dysfunction is a major cause of morbidity and mortality. Hence timely diagnosis and treatment may improve patient outcome [3,4].

Pathophysiology of EHD includes three overlapping stages: 1) an acute necrosis, 2) thrombosis and 3) fibrosis. Acute necrosis is felt to be caused by eosinophilic infiltration and activation with release of inflammatory mediators and toxic proteins. In second stage, at the site of damaged and exposed endocardium, platelets bind with von Willebrand factor and collagen to form a thrombus. Thrombus formation can occur in both ventricles typically at the apices. However, it can be located at the valvular, subvalvular or in the outflow tracts. Systemic thromboembolism remains a major concern of morbidity and mortality in up to 25% of patients. In the final stage, thrombosed endocardium is replaced by fibrosis resulting in scarring, valvular regurgitation and restrictive cardiomyopathy. The clinical presentation of EHD is variable and may range from an asymptomatic myocardial involvement to heart failure syndrome, conduction abnormality, fatal arrhythmia, sudden cardiac death or an acute coronary like syndrome. Arrhythmias are due to fibrosis of the conduction system or myocardial scarring. Acute coronary syndrome is rare but can occur due to embolic coronary artery occlusion [5-7].

It is important to note that EHD can be seen in any cause of eosinophilia or hypereosinophilia such as drugs and hypersensitivity reactions, parasitic or protozoal infections, malignancies or idiopathic hypereosinophilic syndromes [8].

Medications are frequently implicated as an etiology of hypereosinophilia. A wide spectrum of drugs can lead to HE and include antimicrobials, anti-inflammatory, antipsychotics, anticonvulsants, diuretics, inotropes and ACE inhibitors [9,10]. Eosinophilic myocarditis has also been described with hypereosinophilic vasculitides such as eosinophilicgranulomatosis with polyangiitis (EGPA). HE can be reactive or part of a proliferative clone in solid and hematological malignancies such as lung, GIT, urogential tumors, T and B cell lymphomas, acute and chronic myeloid leukemia and myeloproliferative disorders.

Diagnosis

Endomyocardial biopsy is the reference standard test for the definite diagnosis of EHD. However, biopsy is often not performed due to its invasive nature, leaving the diagnosis made based on the appropriate clinical data and imaging modalities. It is important to note that a biopsy may be negative in cases with focal cardiac involvement. Eosinophilia is present in the majority of the patients with EHD. Electrocardiographic changes are common but nonspecific and may include criteria for left ventricular hypertrophy, arrhythmias, first degree AV block. T-wave inversions are most frequently found as seen in our case. T-Wave inversions are likely manifestations of subendocardial injury and fibrosis [11]. Echocardiography plays a vital role in suspecting and identifying EHD. Echocardiographic findings may vary depending on stage of presentation and degree of myocardial involvement. Characteristic echocardiographic features of EHD include endomyocardial thickening in up to 68% of the cases, apical obliteration/thickening due to thrombus formation and restricted posterior mitral leaflet. Other conditions such as LV noncompaction, apical hypertrophic cardiomyopathy and isolated LV apical thrombus may mimic the echocardiographic images of EHD. Different imaging techniques such as use of echo contrast agents, transesophageal echocardiography with three dimension windows and magnetic resonance imaging (MRI) can make the differentiation among these conditions [11-13]. In fulminant cases of myocarditis, a non-dilated, thickened, and hypocontractile left ventricle (LV) is usually observed. Myocardial fibrosis can result in restrictive cardiomyopathy in later stages which can be assessed with Doppler data. Cardiac MRI has higher sensitivity and specificity than any other imaging modalities and contrast-enhanced Cardiac MRI can identify inflammation and fibrosis in its early stages even when echocardiography findings may be normal [14-17]. Interestingly, the severity of eosinophilia was directly related with the severity of MRI findings in few case reports [17]. In our patient, Cardiac MRI showed circumferential apical endocardial thickening/ fibrosis after gadolinium contrast administration and LV apical thrombus, which is pathognomonic of EHD. Cardiac computed tomography (CT) may be used to evaluate the coronary artery disease as a potential cause of apical thrombus if concomitant wall motion or severe systolic dysfunction is present [18]. Coronary angiography has little role and is only used to rule out coronary artery disease.

Treatment of EM involves both pharmacologic and nonpharmacologic therapies. Pharmacologic therapies include guideline driven therapies specific to cardiac presentation, anticoagulation and steroids. In addition it is important to find the etiology of hypereosinophila and treat it accordingly. Insuspected cases of drug hypersensitivities, offending drug needs to be discontinued and chemotherapeutic agent is used for solid and hematologic malignancies. Patients with Churg Strauss syndrome are treated with steroids with or without steroid sparing agents. Recently non FDA approved therapeutic agents targeting IL-5 receptors as Benralizumab have shown promising reduction in blood and tissue eosinophilia [19].