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Most physicians who practice Western Conventional
Medicine, do not know what glutathione or GSH is. Many who
practice REAL medicine, as opposed to synthetic medicine only
know glutathione as a REDOX mechanism. But glutathione is
far more important than that. Let’s start with glutathione as
the Master Anti-oxidant. As an anti-oxidant, it is made inside
the cells. It is the only anti-oxidant that re-stabilizes itself, most
simply become another free radical. It also re-stabilizes many
other anti-oxidants as well, i.e., Vitamin C. Most anti-oxidants
work on a given type of free radical in a given location, i.e., inside
the cell; the cell membrane; or outside of the cell. Glutathione
works everywhere. Most anti-oxidants work on a given type
of free radical. Glutathione works on all of them. Thus, it restabilizes
itself and others; works anywhere; and on any type of
free radical - that’s impressive!
The highest concentration of glutathione is found in the
liver. Presumably because glutathione plays such a huge part
in detoxification, not only at a cellular level but in the body’s
largest detox organ. Regardless of whether the liver is doing
a Phase I/II or I/II/III or I/II/III/IV glutathione is usually the
last part of the detox process. Glutathione is also required for
regulation of Ca movement, i.e., gating of cardio cell function; and
therefore, important for heart function. The respiratory system
is also dependent on glutathione. The red blood cells require
glutathione in order to both pick up/release both O2 & CO2
Glutathione is also involved in a healthy immune and
inflammatory resolution. Immune cells, i.e., T cells, B cells,
macrophages, TNF, NK, etc., all require glutathione to both develop
and function. In addition, glutathione helps to regulate the ratios
between Th1/Th2 so that auto-immune and other disorders do
not develop. Both directly and indirectly, glutathione is involved
in the regulation of many hormones. For instance, it eliminates
excess estrogens from the liver.
Within the cells, we know that the mitochondria provide
most of the cellular energy in the form of ATP. Glutathione is
the only known compounds that protects the mitochondria. And
of course, the mitochondria are required to provide the fuel to
make the glutathione. Glutathione regulates the production of
Nitric Oxide, (NO) which works in the cardiovascular system as
a vasodilator, but also in the immune system; the neural system;
and involved in hormonal regulation. Our DNA depend on
glutathione to protect it from abnormal reproduction; correcting
it when it is abnormal; or eliminating it cannot be corrected.
Glutathione is also required in protein synthesis as well as in
cellular amino acid transportation.
The telomeres, at the ends of the DNA strands are important
for DNA replication. And while there are other anti-oxidants that
protect the telomeres from free radicals, glutathione is the only
know compound that provokes the creation of new telomeres.
Thus, when it acts in REDOX or against as an anti-oxidant or
in provoke new telomeres, it is a great anti-aging compound.
Yet research is showing that we are making less glutathione,
despite the fact that we need it more than ever, i.e., to help with
detoxification both at a cellular level and in the liver. Historically,
we lost glutathione to issues like age, genetic abnormalities,
stress, poor sleeping habits, infections, injuries, poor diet,
dehydration. However, in today’s world we are also looking it
due to issues like increased synthetic toxic compounds (in our
foods, our pharmacy, our cleaning products, etc.); radiation, too
much sun, sunscreen.
A good diet can provide the nutrients that the gut requires
to send the nutrients to the liver and throughout the body so
that all cells can make glutathione. However, problems with
the GIT process can hinder these nutrients: insufficient salvia;
insufficient hydrochloric acid; insufficient GIT enzymes;
insufficient pre/probiotics; impaired GIT immune function; GIT
inflammatory issues, etc. can all effect if and how nutrients are
metabolized and sent to the liver and elsewhere, thus inhibiting
the cell’s capacity to synthesize glutathione. At a cellular level,
if cells cannot transport amino acids; if the mitochondria are
insufficient or working ineffectively; if the methylation cycles are
not functioning; glutathione is not synthesized. One can easily
identify the cascading effects of insufficient glutathione.