Journal of Otolaryngology | Open Access Journals

Case Report

Endoscopic Resection of a Giant Sinonasal Haemangiopericytoma with Preoperative Embolization and Cyanoacrylate Glue Injections: A Case Report and Literature Review

Longari Fabrizio¹, Cipriani Laura¹, D'Ascanio Luca^2,3*, Lapenna Ruggero¹, Dehgani Mobaraki Puya^1,3 and Ricci Giampietro¹

¹Department of Surgical and Biomedical Sciences, Section of Otorhinolaryngology, University of Perugia, Italy

²Department of Otolaryngology - Head & Neck Surgery, “Carlo Poma“ Civil Hospital, Italy

³Association “Naso Sano“ Onlus, Umbria Regional Registry of Volunteer activities in Health System, Italy

Submission: May 13, 2017; Published: May 24, 2017

*Corresponding author: Luca D'Ascanio, Department of Otolaryngology - Head & Neck Surgery, Carlo Poma, Civil Hospital, Strada Lago Paiolo 10, 46100 Mantova, Italy, Tel: +39-3283186967; Fax: +39-075-5783574; Email: l.dascanio@gmail.com

How to cite this article: Longari F, Cipriani L, D'Ascanio L, Lapenna R, Dehgani M P, et al. Endoscopic Resection of a Giant Sinonasal Haemangiopericytoma with Preoperative Embolization and Cyanoacrylate Glue Injections: A Case Report and Literature Review. Glob J Otolaryngol 2017; 8(1): 555727. DOI: 10.19080/GJO.2017.08.555727

Abstract

Background: Hemangiopericytomas (HPC) are rare mesenchymal tumors, which arise from the degeneration of Zimmerman's pericytes. They develop in the head and neck soft tissues in about 25% of cases and, in more than 50% of cases they involve the sinonasal region, especially the sphenoid sinus and ethmoidal labyrinth.

Methods: We report the case of a 71-year-old caucasian male, with a history of recurrent epistaxis followed by total nasal obstruction and anosmia. Radiographic and endoscopic examinations revealed a multilobed hypervascularized mass (49x 59x 49mm), occupying the nasal cavity and the paranasal sinuses. Pre-operative embolization, followed by intratumoral direct injections of cyanoacrylate glue, was carried out. A completely endoscopic resection was then performed.

Results: Post-operative histopatological and immunoistochemical examinations confirmed a sinonasal HPC. Endoscopic and radiological 2-year follow-up did not show any tumor recurrence.

Conclusion: Endoscopic intranasal excision under endoscopic guidance, with preceded by embolization and direct cyanoacrylate glue injections, is an effective treatment for sinonasal HPC.

Keywords: Tumors; Sinonasal haemangiopericitoma; Epistaxis; Endoscopic sinus surgery .

Introduction

Even though vascular tumors are the most common mesenchymal malignancies of the head and neck soft region, haemangiopericytomas (HPCs) are extremely rare and occur in only 1% of cases [1]. Originally described by Stout and Murray in 1942, HPCs arise from the degeneration of the so-called «pericytes of Zimmermann». These cells, surrounding the basilar membrane and the endothelium of capillaries and venules, act as «mini» baroceptors modifying vessel diameter [2]. As a result of their vascular origin, HPCs are ubiquitous, with a more common skin, musculoskeletal, mediastinal, retroperitoneal and pelvic involvement. In about 25% of cases they develop in the head and neck soft tissues [3] and in more than 50% of cases they involve the sinonasal region, especially the sphenoid sinus and ethmoidal labyrinth [4].

The etiology is still unknown: previous trauma or chronic corticosteroid therapy have been proposed, with no definite scientific confirmation [5]. The peak of incidence is between the sixth and seventh decade of life, with no significant prevalence of race or gender [6]. They have been reported as benign, malignant or borderline, because of their unpredictable clinical evolution: forms with low mitotic activity are reported to produce distant metastases in 15% of cases [7]. The mortality rate can reach 50% within 5-20 years after the first diagnosis [8]. The HPCs developing in the nasal and paranasal districts have some clinical, architectural and histopathological features that make them a separate entity (Sinonasal type haemangiopericytomas, SNTHPCs) [8]. SNTHPCs clinical presentation consists of nasal obstruction and epistaxis. More rarely, the tumor causes headache and/or ocular symptoms. We present the case of a giant SNTHPC endoscopically removed with prior embolization and intralesional injections of cyanoacrylate glue. A review of the literature on this topic is reported.

Case Report

A 71-year-old Caucasian man, with a previous history of intranasal polipectomy in 1986 and 1987, came in 2008 to our observation at the ENT Clinic of Perugia University (Italy) for recurrent epistaxis. Clinical and radiological examination (conventional angiography) showed a hyper vascular lesion. A surgical treatment was proposed to the patient. However, he refused such option. Two years later, he came back for a total nasal obstruction and anosmia. The anterior rhinoscopy showed an unique nasal cavity entirely occupied by a grayish-white bulky painless lesion, with a non-ulcerated and elastic surface. The mass did not show spontaneous or provoked bleeding and displayed a heartbeat synchronous pulse.

The control computed tomography with mean of contrast showed the hyper vascular fleshy mass with a volumetric increase (49 x 59 x 49mm) with respect to the previous exam. It had a multilobed aspect with the involvement of the whole nasal cavity, both ethmoidal labyrinths, both maxillary sinuses, the left frontal sinus and the sphenoid right one. The left lacrimal sac and the corresponding nasolacrimal duct appeared infiltrated, with a bilateral thinning of the lamina papyracea (Figure 1). A conventional angiography was performed to confirm the vascular nature of the tumor: a pathological flow from the branches of the internal maxillary artery and from the anterior and posterior ethmoidal arteries was noticed (Figure 2). A complete tumor embolization was performed with super selective catheterization of the internal maxillary artery with coaxial Rapid Transit® system, using four vials of 10 ml each of 500 micron microspheres. Np embolization of the ethmoidal arteries was carried out to avoid any risk of sight impairment.

Immediately after the embolization and under general anesthesia, three direct intratumoral injections of cyanoacrylate glue were performed. A complete endoscopic resection was then carried out, using a four hands technique. The neoplasm was fully capsulated. The vascular pedicles were found coming from the right ethmoid and sphenopalatine region. After cauterization of the vascular pedicles, a complete excision of the tumor was performed with debrider. The underlying bone was drilled out and a frozen section analysis of soft tissue margins was performed to ensure complete surgical tumor resection. The bleeding was well controlled by cauterization, temporary packing and direct intra tumoral injections of Floseal® hemostatic matrix, without the need for blood transfusion. Then the nasal cavity was buffered with Surgicel® and Merocel®, which was removed after 5 days.

Post-operative histopatological examination showed spindle-shaped cells, with an indistinct cytoplasm and moderate nuclear atypia, placed around medium-sized and small vascular channels with a fine network of pericellular reticuline. They showed immunoistochemical positivity for CD99, BCL2, CD34, CD31 and smoth muscle actin, suggestive for a SNTHPC (Figure 3). The low mitotic index, the absence of necrotic areas or hemorrhage were predictive of a favorable behavior and adiuvant radiotherapy was not performed. The endoscopic and CT scan follow-up has not shown any tumor recurrence so far (Figure 4).

Discussion

Maxillo facial trauma

SNTHPCs are rare mesenchymal tumors, that usually involve the nasal cavity and the ethmoid and sphenoid sinuses. These tumors can occur at any age, however, previous case series suggested a peak incidence during the sixth and seventh decades [6]. The presence of a persistent nasal obstruction associated with epistaxis is the typicl clinical presentation of SNHPCs [1]. Headache or compressive ocular findings of proptosis, epiphora and diplopia are rare, but can be found in case of extended tumor size or orbital extension. Racoussot reported a case of SNTHPC revealed by episodes of acute dacryocystitis [9]. The differential diagnosis from other more common pathologies of the sinonasal district (nasal polyposis, fungus ball, malignancies, encephalocele, etc.) should be made pre-operatively. Even though the final diagnosis is obtained only with histological examination, several authors suggest [1,10-12] avoiding biopsies, especially when the tumor size may cause severe bleeding [13]. However, misdiagnosis can lead to an incorrect surgical approach, with an incomplete excision, which may favor recurrences or metastases.

Pre-operative examinations must include neuroradiological investigation to detect the vascular nature of the tumor and its extension. CT scans of the nose and paranasal sinuses can demonstrate bone involvement, and the intravenous mean of contrast infusion can show tumor enahancement, but it does not allow a clear distinction with inflammatory fluid [14]. Usually, MRI scan shows a solid isointense mass, with a strong enhancement after gadolinium on T1 weighted sequences. On T2 weighted imaging, HPCs appear isointense to low intense, while inflammatory fluids have high-intense signals [12]. The best visualization of the vessel supply of the SNTHPC can be achieved by conventional digital angiography, which helps at the same time to plan a preoperative embolization [15].

Substantial intraoperative bleeding during SNTHPC surgical removal may be a major problem in the management of these highly vascularized tumors. Traditional preoperative embolization by a transarterial approach has proved beneficial but is often limited by the complex vascular anatomy and unfavorable location of such tumors. In our opinion, preoperative direct intralesional injections of cyanoacrylate are recommended, especially in case of extended SNHPCs to avoid severe bleedings and reduce surgical time. Traditionally the open approach (lateral rhinotomy) with or without pre-operative embolization, was the usual technique for the resection of large SNTHPCs [10].

Endoscopic procedures have been widely used in the last two decades, because of the avoidance of facial skin incision, the relatively short operation time, and the reduction of intraoperative bleeding. The use of endoscopic approach allows an excellent visualization of the operating field and a precise localization of the tumor origin even in case of anterior skull base involvement [11]. Direct local application of Floseal® is indicated during the surgical procedure as an adjunct to hemostasis when bleeding control by conventional procedures is insufficient. Floseal® hemostatic matrix is a combination of bovine-derived Gelatin Matrix and a human derived Thrombin Component largely employed in neuro-, cardiovascular and orthopedic surgery.

The histological and immunohistochemical features of the tumor are based on the presence of pleomorphic cells, with circular nuclei. They are surrounded by a reticular stroma and numerous vascular channels that typically exhibit a stag horn branching pattern. A strong immunoreactivity to smooth muscle actin is often detectable. Therefore, the pathological criteria for defining SNHPC malignancy are: tumor size, increased cellularity, cellular pleomorphism, increased mitotic activity, necrosis and hemorrhage [16]. Tumors with more than four mitoses per high- power microscopic field are defined as malignant [17]. A review Author's single case or series of SNHPCs of the last years on the type of treatment and follow-up outcomes are reported has been done. The information obtained, particularly focused in Table 1.

EES: Endonasal Endoscopic Surgery; LR: Lateral Rhinotomy; R: Recurrence; NED: Non Evidence of Desease; DWD: Died with disease; ART: Adiuvant Radiotherapy

Conclusion

SNTHPCs can be successfully managed endoscopically [18-20]. A pre-operative embolization with superselective arterial catheterization should be done. Direct intralesional injection of acrylic glue is a feasible, safe, and effective technique for achieving presurgical devascularization, especially in case of extensive lesions with a complex vascularization. Intra-operative bleeding control can be successfully increased with local use of Floseal® Hemostatic Matrix. Since SNTHPCs should be evaluated as a tumor with a malignant potential, intraoperative frozen sections study of surgical margins followed by the histological and immunohistochemical examination should guide complete tumor resection and the subsequent follow-up.