Macintosh Laryngoscope Assisted Flexible Fiberoptic Endotracheal intubation Versus Flexible Fiberoptic Endotracheal Intubation alone for modified Mallampati III & IV Patients: A Prospective Randomized Controlled Study
Mohamed ghanem* and Alaa Mazy
Mansoura Urology and Nephrology Center-Mansoura University, Mansourah Dakahlia, Egypt
Submission: December 03, 2018; Published: December 13, 2018
*Corresponding author: Mohamed ghanem, Mansoura Urology and Nephrology Center Mansoura University, Mansourah Dakahlia, Egypt
How to cite this article: Mohamed G, Alaa M. Macintosh Laryngoscope Assisted Flexible Fiberoptic Endotracheal intubation Versus Flexible Fiberoptic Endotracheal Intubation alone for modified Mallampati III & IV Patients: A Prospective Randomized Controlled Study. J Anest & Inten Care Med. 2018; 8(1): 555728. DOI: 10.19080/JAICM.2018.08.555728
Abstract
Background: The intubation difficulty of using the flexible FOB could be due to the inability to visualize the glottis and/or failure to advance and railroad the endotracheal tube. The combined use of Macintosh laryngoscope with the flexible FOB could be a safe technique that facilitate the flexible FOB intubation function in non-relaxed spontaneously breathing patients predicted to be difficult for endotracheal intubation.
Methods: A prospective randomized controlled study included 100 patients predicted to be difficult for airway intubation, ASA physical status Ӏ-III, aging 18-65 years. Patients were randomly allocated into two groups 50 patients each, the control group (Group F) in which flexible- video assisted-FOB was used alone and the study group (Group MF) in which combined Macintosh - flexible-video assisted-FOB used for endotracheal intubation under inhalational general anesthesia out of any muscle relaxant use. The study compared the techniques for endotracheal tube insertion time, 1st trial success rate, number of attempts, complications, and hemodynamic changes between both groups.
Results: There were significant decrease in endotracheal tube insertion time Group MF (32.04± 7.8) compared to Group F (68.6 ± 12.24), significant increase in 1st trial success in Group MF 49 (98%) compared to Group F 41 (82%), with acceptable Intubation conditions and hemodynamics for both groups. Conclusion: The combined use of Macintosh laryngoscope with the flexible FOB in predicted difficult endotracheal intubation conditions provides significant decrease in endotracheal tube insertion time (near 50% reduction), significant increase in 1st endotracheal intubation trial success rate, acceptable intubating conditions and hemodynamic stability compared to flexible FOB alone.
Keywords: Endotracheal; Flexible; Fiberoptic; Intubation; Laryngoscopy; Macintosh
The Study Key points
a. The Study Question: Could preliminary Macintosh laryngoscopy improve the performance of flexible Fiberoptic Video Assisted Laryngoscope (FVFOB) during predicted difficult intubation?
b. The study Value: Up till now this is the only clinical research studied the value of combine FOI with Macintosh laryngoscope in difficult intubation predicted airway.
c. The Study Findings: Combined Macintosh with FVFOB provided Significant decrease in EET insertion time, significant increase in 1st trial success, accepted Intubation conditions, and hemodynamics during predicted difficult intubation.
d. Meaning: Macintosh laryngoscope with the FVFOB is feasible and safe intubation technique in spontaneously breathing non-relaxed patients having predicted difficult airway intubation (PDEtt).
Main Text
Background
Variety of devices and new technologies have been developed as intubation tools but still not available in every operative theater. Indirect laryngoscopy methods such as FOB and video laryngoscopes have recently been added to the guidelines by the American Society of Anesthesiologists for management of predicted difficult endotracheal intubation (PDEtt) [1]. Non- tongue protrusion modified Mallampati score (NT-MMT) [2] and thyromental distance are reliable indicators for airway difficulty prediction for endotracheal intubation. A golden rule during predicted difficult intubation and/or difficult mask ventilation is that airway should be safely secured while the patient is still awake. Difficulty during FOB could be due to inability to visualize glottis or to advance and railroad the endotracheal tube (Ett). The success rate of using Macintosh laryngoscope alone versus flexible FOB in predicted difficult airway intubation were respectively 26.1% and 92.6% (p < 0.01). [3]
Hypothesis
The combined use of Macintosh laryngoscope with the FVFOB can facilitate the FOB intubating function and increases its success rate in non-relaxed spontaneously breathing patients PDEtt. Aim of the work: To improve flexible FOB reliability and success rate during difficult intubation conditions.
Procedure
Methods
After study protocol approval by the Human Studies Committee at the University Mansoura International research board approved, this study (IRB) Code Number: R/17.08.102, date 10/9/2017, written informed consent was obtained from all subjects participating in the trial, the trial was registered prior to patient enrolment at the ClinicalTrials.gov (NCT03310866), registration date 16/10/ 2017.
Type of the study
A prospective randomized controlled study on Patients aged 18 to 65years of ASA physical status I to III. All Patients airway was evaluated by NT-MMT airway score (2) and thyromental distance (3) by anesthetists not involved in airway intubation at the preoperative round. The study was designed as a parallel 2-arm, comparing FVFOB [KARL STORZ (FIVE) Flexible Intubation Video Endoscope, C-MAC® Monitor, 8403, zx] (control group=Group F) versus combined FVFOB and Macintosh laryngoscope (study group= Group MF) for PDEtt scheduled for oncology surgery under general anesthesia. After pilot study of 40 cases 20 for each group, sample size obtained using G power program total number of 100 patients 50 patient for each group, patient enrolment, exclusion, and group allocation was clarified in the study chart (Figure1).
Randomization
Patients were allocated randomly by drawing sequentially numbered sealed opaque envelopes contained a softwaregenerated randomization code to receive either Group F or Group MF.
Inclusion criteria
All patients were ASA I-III. Airway criteria: should be of both Modified Mallampati (NT-MMT) Airway score III, or VI with thyromental distance ≤ 5cm (PDEtt), both sexes, aged 18 to 65 year’s old, Scheduled for elective oncology surgery under general anesthesia. Exclusion criteria: Patients with preoperative hemodynamic instability or heart failure, pulmonary diseases pregnancy. Suspected cervical fracture, Deformities of the tongue, mouth, mandible, larynx and maxilla, Prior history of surgery in these regions. Morbid obese BMI> 35, obstructive sleep apnea patients. History of malignant hyperthermia, and allergy to general anesthetics or opioids.
The preoperative preparation
Airway of the Patients was evaluated using NT-MMT by anesthetists who were not involved in airway intubation at the preoperative examination, all patients fasted 6 hours for solid and 2 hours for water before surgery, morning of surgery IV cannula was inserted in the ward before sending the patient to operative theater then preloading with 500 ml Normal saline IV infusion, Glycopyrrolate (7μg/kg IV) was given 20 minutes before airway management for suitable clear dry vision and better quality of topical anesthesia during FVFOB.
Sterile FVFOB was attached to electric power light source vision clarity, anterior and posterior tip movement checked, portex Ett (7.5 mm ID in males, 7 mm in females) railroaded over it. Sterile FVFOB specific airway, Sterile Macintosh direct laryngoscope, its light source check, sterile effective suction machine with a sterile suitable suction catheter attached, size 3 and size 4 sterile laryngeal mask in case needed. In the recovery room pulse oximeter O2 saturation monitor was connected then Airway local anesthesia nebulization sitting Using lidocaine 1mg/kg of 2% lidocaine [4] solution nebulized over 5 minutes via electric nebulizer was done in semi-sitting position in the recovery room 20 minutes prior intubation over 5 liters O2/minute flow.
In the operative room Patients were positioned in the flat supine neutral head position, Then basic monitoring devices were connected includes: Non-invasive blood pressure cuff, Electrocardiography (ECG), pulse oximetry and End tidal Co2 (EtCo2) side-stream Capnogram connected to the oxygenation Mask-circuit complex, after that 1mg/kg lidocaine 2% solution gurgle for 60 seconds to throw out not to swallow[5] The Anesthesiologists Position was arranged for both anesthesiologist to stand at the head of the patient with the assistant anesthetist stood on the left and the FOB intubating anesthetist will stand to the right.
Patients were Pre-oxygenated for 5 minutes with normal tidal breathes of 6.0 L/min 100% O2 via tightly fitting face mask- Magill circuit (Mapleson A) with reservoir bag 2liters [6,7]. Anesthesia induction using single IV bolus of fentanyl (1 μcg/kg) after which sevoflurane inhalational induction (6-8%) was started using the semi-closed ventilator circuit carried over 100% O2 of 6.0 L/min till loss of consciousness with maintained respiratory drive occur. (Anesthesia depth and Loss of consciousness confirmed by mask end-tidal concentrations of sevoflurane just before successful tracheal intubations >4% [8], and loss of the lid-lash reflex) [9]. Fiberoptic Intubation was conducted according each group as follow: Control Group(F) Done by two anesthetists; the 1st anesthetist (assistant) inserted sterile airway with head tilt- chin lift- jaw thrust and the 2nd anesthetist 2nd anesthetist (five years expert in FOB intubation with experience of successful 400 FOB oral intubations) did oral FVFOB along the FOB specific airway, jaw thrust was performed by placing the fingers behind the posterior ramus of the mandible, with the thrust directed upwards and the thumbs caudally. Study Group (MF) Done by two anesthetists; the 1st anesthetist (assistant) did Macintosh Laryngoscope laryngeal exposure with size III blade for all cases (size II blade to be ready in case needed for very short thyromental distance), the 2nd anesthetist ( five years expert in FOB intubation with experience of successful 400 FOB oral intubations) did oral FVFOB by introducing the FOB to the right of the pre-inserted Macintosh laryngoscope blade and directed centrally targeting the laryngeal opening.
After visualizing the glottis straight ahead in both groups; another topicalization sitting spray-as-you-go technique [7] of 1mg/kg lidocaine 2% via the FOB working channel to directly administer local anesthetic to supraglottic and glottic structures during advancement of the instrument, then a propofol bolus dose of 1mg/kg to ensure complete suppression of the airway reflexes and prevent any complications, then Fine adjustments with slight motion of the wrist and elevation or depression of the tip using the angulations (thumb) control lever aid in steering the scope toward the vocal cords, FVFOB was then introduced through the vocal cords visualizing the tracheal rings, to the level of the midtrachea (optimal tube positioning 2-3 cm above the carina), then tracheal tube was introduced over the FVFOB shaft into the trachea (Ett should be turned gently counterclockwise with retraction and then re-advanced if resistance is encountered during placement to decrease the occurrence of laryngeal trauma [10].
Correct Ett placement was confirmed by FVFOB view of carina and tracheal rings together with the Capnogram waveform [11]. The FVFOB was then withdrawn as the tube is held in place by hand, After ETT placement and securing a bolus dose of 0.5 mg/kg Rocuronium muscle relaxant will be given for operative relaxation issue. Primary and secondary outcome variables data were collected. Technique Failure and complication management according to ABCD as follow
a. Failed FOB intubation cases were managed as follow: (failed intubation was defined as); Case exposed to 3 trials of FOB intubation with insertion time (IT) 90 second for each trial and couldn’t be intubated. Any complication leads to failed intubation 3 trials to be reported and excluded from the study and replaced by another case.
b. Prevention: Sufficient inhalational anesthetic depth (MAC>1.5) to ensure airway reflexes suppression.
c. Management: I) Removing the cause: Any triggering stimulation secretion suction ensuring a clear larynx. II) Use Glidoscope as a standby intubation instrument in emergency situation [12]. If a Glidoscope also failed the decision is to cancel surgery and to awake the patient [13]. III)- According to Adult Difficult Airway Society 2015 guidelines [12] sequence of events was arranged in three planes (A, B, C) if failed intubation encountered during the study
d. Plan A: Maintaining oxygenation via Supraglottic Airway Devise (SAD) insertion either to wake the patient or to intubate through SAD or to continue with the SAD or if CICO (can’t intubate can’t oxygenate) go for plan C
e. Plan B: Face mask ventilation if ventilating wakes the patient, can’t intubate can’t oxygenate (CICO) go for plan C. f. Plan C: Emergency front of the neck access (cricothyrotomy).
Cases with Laryngospasm management [14] with hydrocortisone 1mg/kg bolus, Application of CPAP with 100% oxygen. I.V. propofol (0.5 mg kg) increments if not effective Succinylcholine1mg/kg to be given. Cases with Bronchospasm management [14] increase anesthesia depth, if ventilation through ETT difficult/impossible, check tube position and exclude blocked/misplaced tube, in non-intubated patients exclude laryngospasm and consider aspiration. Drug therapy Magnesium sulphate 50mg.kg-1 IV over 20min (max 2g), Hydrocortisone: 200mg IV 6 hourly Ketamine: Bolus 10-20mg. Infusion 1-3mg.kg, in extremis: Epinephrine (Adrenaline) Nebulized: 5mls 1:1000 or Intravenous 10mcg (0.1ml 1:10,000) to 100mcg (1ml 1:10,000) titrated to response.
Cases with Apnea &desaturation Apnea was defined as the cessation of spontaneous ventilation associated with an absence of expired carbon dioxide (by a side stream carbon dioxide analyzer) lasting >10seconds [10,11] Desaturation limit ≤ 90% arterial pulse oximeter reading. Management adequate pulmonary ventilation was ensured through a facial mask (handbag, ventilation) then according to adult difficult airway society 2015 guidelines [11]
Study Outcomes (Qualitative criteria for FOI)
Primary outcome
Endotracheal intubation insertion time (EttIT), defined as Time from introduction of the tip of the FOB laryngoscope till carbon dioxide appeared on the capnography after intubation with ETT in the laryngeal inlet down to the trachea.
Secondary outcome
Intubating conditions scoring: each parameter was scored as follow for statistical analyses
a. Modified Mallampati = (III=1, IV=2).
b. Thyromental distance≤ 5cm (in centimeters by the original patient measurement)
c. Jaw relaxation = (Relaxed = 0, not fully =1, poor = 2).
d. Resistance to FOI (no= 0, slight =1, active = 2).
e. Vocal cord position (Abducted=0, Intermediate=1, Closed=2).
f. Neck movements during ETT positioning or cuff inflation= (no=0, slight=1 vigorous=2) [15].
Intubation technique conditions
Trials success rate = number of patients intubated within the 1st 90 seconds in each group. 2-Failed ETT intubation > 270 seconds (3 successive FOB intubation separate trials 90 seconds each on 3 time separated by oxygenation).
Hemodynamics changes after ETT insertion
Systolic Noninvasive Blood Pressure (SNIBP) measured Every 1 min, Heart Rate (HR) both SNIBP and HR were recorded basal and just after ETT in the trachea, and EtCO2 when detected to be recorded. Desaturation ≤90%. (Yes=1, No=0). End tidal Co2 (EtCO2) after intubation.
Statistical Data management
The Sample size was calculated Using G Power program. Based on pilot study of 40 patients 20 for each group (as no previous study compared combined use of FVFOB and Macintosh laryngoscope in PDEtt cases.) yielding an, Effect size d=0.6676508, α error= 0.05, Power (1-β error) =0.85.
Output
Result in Sample size lower limit of 42 for each group which hence 50 patients were assigned for each group with Total sample size=100 patients and consequently 130 patients were enrolled to compensate dropped cases.
Data were analyzed using SPSS software (version 16.0 for Windows; SPSS Inc., Chicago, IL, USA). The data was tested for normality using the Shapiro test and Kolmogorov-Smirnov test. Descriptive data were calculated for all variables (qualitative) that were presented as frequencies and percentages, the analytic data was expressed as means and standard deviation (M±SD), median and range (M&R). Independent sample-t-test was used for comparing the continuous parametric variables and, Chi-square test or Fisher’s exact test (for categorical data). The statistical significance level was set at ≤ 0.05 and highly statistical level was set at ≤ 0.01.
Results
In this present study, intubation technique conditions (Table 1) showed significant decrease in EET insertion time in Group MF (32.04± 7.8 seconds) compared to Group F (68.6 ± 12.24 seconds) P<0.001, significant increase in 1st trial success in Group MF 49 (98%) compared to Group F 41 (82%) P=0.008. Intubating conditions scoring (Table 2) showed no significant difference in between groups as regard jaw relaxation, neck movement, and air way resistance to ETT, vocal Cord position, and ETT induced coughing. Hemodynamically (Table 3) there were significant increase in NISBP&HR readings just after ETT in comparison to the basal reading inside each group, Also significant decrease in post Ett insertion EtCo2 in group MF compared to group F with no significant difference as regard desaturation during Ett and EtCo2. Patient demographics (Table 4) showed no significant difference in between groups including Modified Mallampati score, and Thyromental distance. Failed FOB intubation cases (8 cases for both groups), cases with side effects and complications such as desaturation (3 cases for both groups) were managed according to (ABCD) discussed before in the methodology.
Data are presented in mean ± SD, or number (%), * = Significant value p≤ 0.05, and median &range. (*) There is significant table shows significant decrease in ETT insertion time and significant increase in 1st trial success in group MF in comparison to group F.
Data are presented in mean ± (SD), or number (%), this table shows no significant differences in between both groups as regard intubation conditions scoring enumerated in the table.
Data are presented in (Mean ± SD), or number (%).This table shows significant increase # in both systolic SNIBP and after intubation values heart rate in comparison to basal readings inside each group. Also significant decrease in post Ett insertion EtCo2 in group MF compared to group F * Significant difference, p. value ≤ 0.05.
Data are presented in mean ± SD, or number (%), this table shows no significant differences in between both groups as regard patients demographic variables enumerated in the table.
Discussion
No previous clinical study analyzed the effect of Combined Macintosh laryngoscope with Flexible FOB in PDEtt airways, so that we carried out a pilot study to calculate a statistically effective sample size. In this present study, we hypothesized that combined use of Macintosh laryngoscope with the FVFOB could be feasible and safe technique that facilitate the FOB intubation function in PDEtt.
Difficult airway prediction and the device used instead of Macintosh laryngoscope still a critical issue, despite the fact that el Ganzouri risk index high accuracy in PDEtt and the advanced video laryngoscopy technology both improved laryngeal structures visualization [16]. Difficult Airway Society 2015 [12] for management of PDEtt in adults advised Video laryngoscope as the first choice [17]. Flexible FOB laryngoscope remains the gold standard tool in intubating predicted and unpredicted difficult airway situations. Incidence of difficulty in passing a tracheal tube over an orally inserted FOB varies considerably between studies, so that the need to improve Feasibility and success rate of flexible FOB stay challenging all the time.
The present study showed significant decrease (near 50% reduction) in EET insertion time in Group MF (32.04± 7.8 seconds) compared to Group F (68.6 ± 12.24) P<0.001, significant increase in 1st trial success in Group MF 49 (98%) compared to Group F 41 (82%) P=0.008 higher than previous studies [18,19] done on flexible FOB laryngoscope alone, this can be explained by the fact that Macintosh blade prevented the backward displacement Oropharyngeal structures such as the tongue, soft palate and epiglottis which may close the airway during FOB intubation.
Previous study on FOB alone in difficult intubation patients such as, Calogero et al. (2015) [3] reported that FOB 1st trial success of (92.6%) in PDEtt patients, Salma et al. 2015 [20] reported a FOB success rate of (73.3%) and EttIT (62.97 ± 37.5 seconds), meanwhile in our present study adding Macintosh blade before FOB has lowered the tracheal tube insertion time down to 32.04± 7.8 seconds (nearly 50% less) and increased the intubation success rate Group MF 98% in comparison to the previous studies[3,20] results indicating great feasibility of combined use of FOB and Macintosh laryngoscope during difficult intubation conditions.
As regard comparison to other airway devices combinations with FOB: All the previous studies were done for non-difficult airway patients, except Aziz et al. [21] who documented 93% first attempt success rate in predicted difficult airway, a result lower than our result (98% 1st attempt success rate), Moore et al. [22] showed a high success rate (96%) of the same intubation technique in morbidly obese patients. Gupta et al. [23], documented that, during intubating highly seated larynx the Combined Flexible FOB simultaneously with C-MAC VLS enhanced visualization of intubation field and decreased chances of trauma to delicate soft tissue structures. Our opinion is that all operative theaters all over the world may not have both C-MAC and FOB laryngoscope at the same time but Macintosh laryngoscope is popular present every were, cheap, and widely used as primitive goldstone tool for classic Ett that guarantee airway opening with wide space view prior the entrance of the flexible FOB laryngoscope which is also the goldstone basic tool for predicted difficult endotracheal intubation which is the field of our study. All the previous mentioned studies airway intubating techniques were comparable to our technique results regarding tracheal intubation success rate and insertion time.
The reliability of rigid video laryngoscopes in difficult airways, Niforopoulou et al. [24] postulated that despite clear glottis visualization, tracheal insertion of the Ett with video laryngoscopes may fail, in our present study combined FVFOB (which guarantee Ett advancement over its shaft with the aid of the FVFOB tip upward movement ability to reach the highly seated larynx) with Macintosh laryngoscope blade pre-exposure (which could guarantee better airway opening and rapid glottis access during Ett insertion).
Inhalational anesthesia with airway LA topicalization and fentanyl analgesia without IV muscle relaxants, maintain the respiratory drive without exposing the patient to the stress of the awake airway instrumentation despite that, still has the drawback of unpredictable effect on the patient respiratory drive when used in not enough or more than enough doses, despite that we can control the dose, concentration, and delivery rate of the inhalational drug guided by the end tidal sevoflurane concentration if bispectral index is not available. In line with our anesthesia induction technique, Tan et al. [25] documented that sevoflurane combination with remifentanil anesthesia induction for FOB intubation, provided fast induction and good intubation condition with stable hemodynamics.
Long time back, Stacey et al. [26] used FOB with Macintosh laryngoscope but in normal- non-difficult airway patients and found a clear airway in 92% of the patients at the level of the larynx. On the other hand, Johnson et al. [27] published a case report advised that Macintosh laryngoscope could help during FOB intubation during difficult airway conditions. Up till now this is the only clinical research studied the value of combine FOI with Macintosh laryngoscope in difficult intubation predicted airway.
FOB intubation has three steps; visualization of the glottis with FOB, passing the FOB through the glottis into trachea till carina, and lastly railroading the Ett over the FOB into the trachea [28]. Backward displacement Oropharyngeal structures may close the airway adding difficulties during FOB under general anesthesia. Using airways, lingual traction and jaw thrust are the maneuvers that may help to overcome this problem. Difficult Airway intubation tool that guarantee the best airway opening simultaneously with glottis opening easy rapid access would be the most ideal, and this could never be achieved by using single instrument.
Clinical implications supporting the hypothesis: A comparable application to our technique is that of the Sensa Scope®, a hybrid intubation endoscope which guarantee safety, easy-to-handle, and effective video-assisted intubation. Has combined rigid and flexible parts. Its S-shaped rigid segment enables a very intuitive handling by one hand only, thus leaving the left hand free to operate a conventional laryngoscope. The device tip can be controlled via a steering handle same as FOB. Its Ett insertion success rate is 97% nearly similar to our intubation success rate in this present study (98%) [29].
Study limitations
a. Patients with Cervical spine instability or trauma may not benefit from this technique as it does not guarantee cervical vertebra immobility due to upward curved Macintosh blade, in opposition, Yumul et al. [29] advised that C-MAC is superior to fiberoptic flexible laryngoscope as regard the time required to obtain glottic view and successful placement of the tracheal tube in patients requiring cervical spine immobilization.
b. No available Bi-spectral index in the hospital (anesthesia depth detector) so we used end tidal sevoflurane concentration and lid lash reflex.
c. General anesthesia induction technique in our study utilizing inhalational sevoflurane avoiding IV muscle relaxation still has the drawback of unpredictable effect on the patient respiratory drive when used in not enough or more than enough doses even so still in hand as we can control the dose, concentration, and delivery rate of the inhalational drug using end tidal sevoflurane concentration >5.5% and lid lash reflex if bispectrality index is not available.
d. Still we can’t guarantee 100% difficult airway prediction while using two or three scoring airway systems, so we used an internal scoring system NT-MMS and an external scoring system thyromental distance to predict as far as possible the difficult airways to be included in our study.
e. This muscle relaxant free technique may be of less comfortable to the intubator but provided a totally accepted intubation circumstances, patient safety depending on the maintained respiratory derive all over the technique.
Conclusion
The combined use of Macintosh laryngoscope with the flexible FOB in predicted difficult endotracheal intubation conditions provides significant decrease in endotracheal tube insertion time (near 50% reduction), significant increase in 1st endotracheal intubation trial success rate, acceptable intubating conditions and hemodynamic stability compared to flexible FOB alone.
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