The development of disc degeneration is cell-mediated reaction to progressive structural malfunction. A degenerate disc is sign of ageing which lead to failure of structural abnormalities. Intervertebral disc degeneration may lead to biological and physical mechanism because of adjective remodeling.
Degeneration of lumber disc mainly takes place in humans. There are several factors like aging, collagen abnormalities, apoptosis, vascular in growth that are according to this condition. Disc is active thing in itself that carry consequential technique for self repair . Disc degeneration process is an abnormal cell mediated response to continuous structure failure combined with accelerated or faster signs of aging.
Inter vertebral disc are fibro cartilaginous pads which permits limited movements for resisting spinal compression. The intervertebral disc is consisting of elements like central portion of disc which contains nucleus populous whereas outer portion is annuls fibrosis. Nucleus populous consist of cells from primitive notochord and annuls fibrosis is composed of concentric layers of inter-mined annulas bands. , for resisting forces on the lumbar spine, these annular bands are designed in specific pattern further annular bands are divided into its inner fibers and outer fibers or s harpy fibers attached to vertebral body. The anterior and posterior longitudinal ligament strengthens the disc space. The posterior longitudinal ligament is considered less strong than anterior longitudinal ligament because all attaches more toughly to vertebral edges .
Disc is a structure of low metabolic rate and its nutrition is received by the process of diffusion and supplied via capillary beds of end plate of cartilaginous vertebral body  with the application of acetyl chlorine the blood flow of these capillary bed increases which is under the human control . The blood is supplied from the interosseous arteries from distal branches which also supplies the vertebral body . Any kind of change in vascular supply rises to disc degeneration.
Type 1 collagen is mainly found in skin, tendon, bone, and this collagen also found in annulus fibrosis and nucleus pulpous in normal and pathologically degenerated discs. In areas of minor disc degeneration type 2 and type 9 found to be elevated  (Figures 1 & 2).
The main cause of disc degeneration is considered past medical conditions like arthritis, osteoporosis, and disc aging, histological changes like decrease blood supply to vertebral endplate, decreased disc cell density and some changes also occurs due to decompressed nucleus .
Lower back Pain is the major symptom for the intervertebral disc degeneration. After taking the medical history of the patient will be send for radio imaging X ray, CT scan, MRI, disco gram to identify the herniated and compressed disc [9,10].
Medical management of intervertebral disc degeneration includes intake of analgesics to reduce pain like acetaminophen, steroids for reducing swelling of nerves. Non- steroidal anti inflammatory drugs like aspirin are used to reduce the inflammation. Surgical treatment is to restore disk space height as well as to decompress spinal nerves but in case of disc degeneration surgery is recommended rarely unless symptoms have not improved with medical treatment or other therapies. It involves two surgeries like spinal fusion and motion preservation surgery. In spinal fusion the bony vertebrae (1 or 2) fused together permanently whereas motion preservation surgery is done to steady spine without bones fusion together.It includes artificial disc replacement in which damaged disc is removed [11,12].