The Chemistry of a Schizophrenic
Paul TE Cusack*
BSCE, DULE, 23 Park Ave, Saint john, NB E2J 1R2, Canada
Submission: June 16, 2023;Published: September 11, 2023
*Corresponding author: Paul TE Cusack, BSCE, DULE, 23 Park Ave. Saint john, NB E2J 1R2, Canada
How to cite this article: Paul TE C. The Chemistry of a Schizophrenic. Organic & Medicinal Chem IJ. 2023; 12(5): 555848. DOI: 10.19080/OMCIJ.2023.12.555848
Abstract
In this paper, we consider the case of a schizophrenic and his chemistry. The amin is to develop chemistry for all those who have schizophrenia. His mother had Grave’s disease. She drank a lot of tea. We will see how this leads to schizophrenia. Schizophrenia is caused by a virus, either H Pylori or cyanobacteria. This explains the fever he experienced at the onset of the Sz when he was 30 years old.
Keywords: Schizophrenia; H Pylori; Cyanobacteria
Introduction
In this paper, we consider one case to develop the chemistry of schizophrenia. The patient is a 56-year-old Caucasian male who has had SZ for 36 years. He lives on the seacoast. His mother has Alzheimer Disease as well as Grave’s Disease. She drank a lot of tea. This combination leads to schizophrenia as we show in this paper. First, we provide balanced chemical equations involving zinc and sulphuric acid.
Schizophrenia is known to be a Northern Hemisphere problem. I suggest it is because of the low temperatures. The critical temperature is 3.9 C.
Also, it is known to be an Island problem. Islands are at sea level where the oxygen is denser and there is a sea mist (NaCL +H2O).
Ireland which has a marked increase in people with Sz has the critical low temperature of 3.9deg C. They drink a lot of tea and alcohol in Ireland. Tea has butanoic acid and alcohol (OH-) leads to H2O2 a nerve toxin.
The pineal gland in Schizophrenia is smaller than normal. The hypothalamus, the link between the endocrine system and the nervous system affects the thyroid, the TSH (Thyroid Stimulating Hormone). TSH affect I2 (Thyroid) which controls the gastrointestinal tract. H Pylori is involved in the stomach.
The patient’s mother has Grave’s disease (Hypothyroidism) . She also drank a lot of tea (butanoic acid). Grave’s is an autoimmune system disease.
Butanoic Acid Leads to
•Asthma
•Crohn’s Disease
•Ulcerates Colitis
•Colorectal Cancer
•IBS
•Autism
The patient has IBS and is likely Autism.
Carbon monoxide is a nerve toxin and Hydrogen Peroxide causes cancers.
Note: The developing nervous system is particularly sensitive
to carbon monoxide. This explains the cancers, and the mental
retardation and the schizophrenia in the Irish populations.
At sea level STP
P=1.01.325KPa
O2 =15.999x 2=32 x 6.022=192.69
M=Ln t
t=eM=e192.69=6.828
GMP: E=3.93=M
Temp=t=KE=1/2Mv²
=1/2(3.93)(1/√2)²
=1/101.781)=1/P
=Temp=KE=t
KE=3.93 deg C in Dublin
Conclusion
So that’s the chemistry of one case of a schizophrenic. The virus may be H Pylori or Cyanobacteria. We can project that this is the cause of schizophrenia..
References
- McKeown NB (1998) Phthalocyanine Materials: synthesis, structure, and function. Cambridge UK New York 14(3).
- Bıyıklıoğlu Z, Durmus M, Kantekin H (2010) Synthesis, photophysical and photochemical properties of quinoline substituted zinc (II) phthalocyanines and their quaternized derivatives. J Photochem Photobiol A: Chem 211 (1): 32-41.
- Yao CB, Zhang Y, Chen DT, Yin HT, Yu CQ, et al. (2013) Study of All-Optical Switching and Optical Limiting Properties in Phenoxy-Phthalocyanines Liquid. J Opt Laser Technol 47: 228-231.
- Güzel E, Yaşa Atmaca G, Erdoğmuş A, Koçak MB (2017) Novel Sulfonated Hydrophilic Indium (III) and Gallium (III) Phthalocyanine Photosensitizers: Preparation and Investigation of Photophysicochemical Properties. J Coord Chem 70 (15): 2659-2670.
- Güzel E, Günsel A, Bilgiçli AT, Atmaca GY, Erdoğmuş A, et al. (2017) Synthesis and Photophysicochemical Properties of Novel Thiadiazole-Substituted Zinc (II), Gallium (III) and Silicon (IV) Phthalocyanines for Photodynamic Therapy. J Inorganica Chim Acta 467(1): 169-176.
- Çimen Y, Ermiş E, Dumludağ F, Özkaya AR, Salih B, et al. (2014) Synthesis, Characterization, Electrochemistry and VOC Sensing Properties of Novel Ball-Type Dinuclear Metallo phthalocyanines. J Sens Actuators B Chem 202(31): 1137-1147.
- Ağırtaş MS, Altındal A, Salih B, Saydam S, Bekaroğlu Ö (2011) Synthesis, Characterization, and Electrochemical and Electrical Properties of Novel Mono and Ball-Type Metallophthalocyanines with Four 9,9-Bis(4-Hydroxyphenyl) Fluorene. J Chem Soc Dalton trans 40 (13): 3315-3324.
- Jiang Y, Lu Y, Lv X, Han D, Zhang Q, et al. (2013) Enhanced catalytic performance of Pt-Free Iron phthalocyanine by graphene support for efficient oxygen reduction reaction. J ACS Catalysis 3(6): 1263-1271.
- Walter MG, Rudine AB, Wamser CC (2010) Porphyrins and Phthalocyanines in Solar Photovoltaic Cells. J Porphyr Phthalocyanines 14 (9): 759-792.
- Donders CA, Liu SX, Loosli C, Sanguinet L, Neels A, et al. (2006) Synthesis of Tetrathiafulvalene-Annulated Phthalocyanine. J Tetrahedron Lett 62 (15): 3543-3549.
- Shilpa Harish T, Viswanath P (2016) Annealing Assisted Structural and Surface Morphological Changes in Langmuir–Blodgett Films of Nickel Octabutoxy Phthalocyanine. J Thin Solid Films 598(1): 170-176.
- Bilgiçli A. T, Kandaz M, Özkaya A. R, Salih B (2009) Tetracids-Phthalocyanines Bearing Electron-Withdrawing Fluoro Functionality: Synthesis, Spectroscopy, and Electrochemistry. Heteroatom Chemistry 20(5): 262-271.
- Lukyanets EA, Nemykin VN (2010) The Key Role of Peripheral Substituents in the Chemistry of Phthalocyanines and Their Analogs. J Porphyr Phthalocyanines 14(1): 1-40.
- Amaral GP, Puntel GO, Dalla Corte CL, Dobrachinski F, Barcelos RP, et al. (2012) The Antioxidant Properties of Different Phthalocyanines. J Toxicol In Vitro 26 (1): 125-132.
- Ağırtaş MS, Çelebi M, Gümüş S, Özdemir S, Okumuş V (2013) New Water Soluble Phenoxy Phenyl Diazenyl Benzoic Acid Substituted Phthalocyanine Derivatives: Synthesis, Antioxidant Activities, Atypical Aggregation Behavior and Electronic Properties. J Dyes Pigm 99(2): 423-431.
- Pankuch GA, Jacobs MR, Appelbaum PC (1993) New Water Soluble Phenoxy Phenyl Diazenyl Benzoic Acid Substituted Phthalocyanine Derivatives: Synthesis, Antioxidant Activities, Atypical Aggregation Behavior and Electronic Properties. J Antimicrob Agents Chemother 37(8): 1649-1654.
- Young JG, Onyebuagu W (1990) Synthesis and Characterization of Di-Disubstituted Phthalocyanines. J Org Chem Res 55 (7): 2155-2159.
- Perrin BDD, Armarego WLF (1989) Purification of Laboratory Chemicals. Aufl Oxford Pergamon Press J Acta Hydroch Hydrob 17(6): 632-632.
- Kalemba D, Kunicka A (2003) Antibacterial and antifungal properties of essential oils. J Curr Med Chem 10(10): 813-829.
- Arendrup MC, Estrella MC, Florl CL, Hope W, AFST E (2017) Method for the Determination of Broth Dilution Minimum Inhibitory Concentrations of Antifungal Agents for yeasts. EUCAST Defin. Doc E DEF 7. 3.1.
- (1998) National Committee for clinical laboratory standard. Referece method for broth dilution antifungal susceptibility testing of conidium -forming filamentous fungi. Proposed standard M38-P. Wayne, PA: National Committee for clinical laboratory standard.
- Kaspady M, Narayanaswamy VK, Raju M, Gopal (2009) Synthesis, Antibacterial Activity of 2,4-Disubstituted Oxazoles and Thiazoles as Bioisosteres. J Lett Drug Des Discov 6(1): 21-28.
- Lamagni TL, Evans BG, Shigematsu M, Johnson EM (2001) Emerging trends in the epidemiology of invasive mycoses in England and Wales. J Epidemiol Infect 126(3): 397-414.
- Samaranayake LP, Leung WK, Jin L (2009) Oral mucosal fungal infections. J Periodontol 49: 39-59.
- Akçay HT, Bayrak R, Karslioğlu S, Şahin E (2012) Synthesis, Characterization and Spectroscopic Studies of Novel Peripherally Tetra-Imidazole Substituted Phthalocyanine and Its Metal Complexes, the Computational and Experimental Studies of the Novel Phthalonitrile Derivative. Journal of Organometallic Chemistry. J Organomet Chem 713: 1-10.
- Değirmencioğlu İ, Bayrak R, Er M, Serbest K (2009) The Microwave-Assisted Synthesis and Structural Characterization of Novel, Dithia-Bridged Polymeric Phthalocyanines Containing a Substituted Thiophenylamine Schiff Base. J Dyes Pigm 83(1): 51-58.
- Makhseed S, Samuel J (2009) The Synthesis and Characterization of Zincphthalocyanines Bearing Functionalized Bulky Phenoxy Substituents. J Dyes Pigm 82(1): 1-8 5.
- Arslanoglu Y, Mertsevim A, Hamuryudan E, Gul A (2006) Near-IR Absorbing Phthalocyanines. J Dyes Pigm 68(2-3): 129-132.
- Sommerauer M, Rager C, Hanack M (1996) Am Chem Soc 118(42): 10085-10093.
- Koca A, Kalkan A, Bayır ZA (2011) Electrocatalytic Oxygen Reduction and Hydrogen Evolution Reactions on Phthalocyanine Modified Electrodes: Electrochemical, in Situ Spectro electrochemical, and in Situ Electrocolorimetric Monitoring. J Electrochim Acta 56(16): 5513-5525.
- Nyokong T, Isago H (2004) The Renaissance in Optical Spectroscopy of Phthalocyanines and Other Tetraazaporphyrins. J Porphyr Phthalocyanines 8(9): 1083-1090.
- Mayer UA (1979) A semiempirical model for the description of solvent effects on chemical reactions. J Pure & Appl Chem 51: 1697-1712.
- Komarov EV, Komarov VN (1974) Extraction Systems with Associated Extractants. J Russ Chem Rev 43(4) : 263-275.
- Correia RF, Andrade SM, Viseu MI (2012) Aggregation and Disaggregation of Anionic Aluminum Phthalocyanines in Cationic Pre-Micelle and Micelle Media: A Fluorescence Study. J Photochem Photobiol A: Chem 235: 21-28.
- Bıyıklıoğlu Z, Durmuş M, Kantekin H (2010) Synthesis, Photophysical and Photochemical Properties of Quinoline Substituted Zinc (II) Phthalocyanines and Their Quaternized Derivatives. J Photochem Photobiol A: Chem 211(1): 32-41.
- Dominguez DD, Snow AW, Shirk JS, Pong RGS (2001) Polyethylene oxide capped Phthalocyanines: Limiting Phthalocyanine Aggregation to Dimer Formation. J Porphyr Phthalocyanines 5(7): 582-592.
- Akkurt HYY, Okur AI, Gül A (2012) Unsymmetrical Phthalocyanines with Cyclopalladated Azo Functions. J Porphyr Phthalocyanines 16(2): 192-199.
- Salih Ağırtas M, Dede E, Gümüs S, Dündar A, Okumus V (2014) Metallo Phthalocyanines bearing 2-Isopropyl-6-methylpyrimidin-4-yloxy Substituents: Synthesis, Characterization, Aggregation Behavior, Antioxidant and Antibacterial Activity, and Electronic Properties. J Zeitschrift für Anorgan Allgemeine Chem 640(10): 1953-1959.
- Santos DA, Hamdan JS (2005) Evaluation of broth microdilution antifungal susceptibility testing conditions for Trichophyton rubrum. J Clin Microbio 43(4): 1917-1920.