Opinion

Synthesis and Characterization of Alkyne Derivatives as Antifungal Agents

Masoomeh Shirzad and Soroush Sardari*

Department of Medical Biotechnology, Biotechnology Research Center, Tehran, Iran

Submission: July 28, 2018; Published: August 03, 2018

*Corresponding author: Soroush Sardari, Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Tel: +989122632484, fax: +98 (21) 6648-0780, Email: ssardari@hotmail.com

How to cite this article: Masoomeh Shirzad, Soroush Sardari. Synthesis and Characterization of Alkyne Derivatives as Antifungal Agents. Organic & Medicinal Chem IJ. 2018; 7(4): 555716. DOI: 10.19080/OMCIJ.2018.07.555716

Opinion

Alkyne derivatives play an important role in the pharmaceutical industry. Alkynes are organic hydrocarbons with at least one carbon-carbon triple bond such as acetylenyl and propargyl substituents and. Alkyne derivatives could be used as a molecular probe to study biological processes and corresponding diseases such as cancer and also find new therapy against the disease. To confirm the identity of the synthesized alkyne derivatives, the product was characterized by analytical methods. Antifungal activity of the new alkyne derivative could be evaluated by bioassay study of synthesized alkyne derivatives in vitro and in vivo environments. Thus, a deeper understanding of molecular phenomena in cellular process could be provided.

Synthesis and Characterization of Alkyne derivatives

Alkynyl groups are presented in some drugs such as antifungal agents. Haloprogin and terbinafine are common antifungal agents. Alkynes and alkynyl groups are classified as non-polar compounds and the smaller alkynes have gaseous state at room temperature. Alkynes have much higher boiling points than the corresponding alkanes. Alkynes were reduced with metal catalysts easily to provide alkanes [1]. Physicochemical and biological activity of a known compound could be varied by addition of the alkynyl group to the compound, so these compounds may be shown higher affinity at relevant targets such as receptor and enzyme.

With the follow of diagnosis all inguinal hernias are considered for surgical treatment. With the time, progression of a hernia is obvious and most surgeons consider repairing all inguinal hernias at an earliest. Inguinal hernia being benign disease and it repair result complications in elective setting are only rare and minor. After emergency repairs nevertheless, complications develop may be more dramatic and frequent, even with record of mortality [3,4]. It is especially the reason being patient is an elder [5,6]. In elective setting repair therefore is recommended generally.

To develop antifungal biomaterials such as starch derivative, azide-alkyne cycloaddition was used, and the novel starch derivatives were characterized by FTIR, 1H NMR, 13C NMR, and elemental analysis. The obtained results showed the enhancement of antifungal activity of the synthesized starch derivatives [3]. Also, azide-alkyne cycloaddition was used to synthesize chitosan derivatives to enhance antifungal activity of the synthesized chitosan derivatives. These synthetic strategies were used to prepare novel antifungal biomaterials and also cluster-alkyne complexes [4,5].

Applications

Glycidyl triazolyl polymer (GTP), which is the product of cycloaddition reaction between glycidyl azide polymer and alkyne derivatives, could be used to synthesize GTP-based polymer materials such as biomedical materials, self-healing and stimuli-responsive materials. Linear polyethylene glycol (PEG) molecules have the functional groups only at both ends, but GTP homopolymers and copolymers are multi functionalized PEG derivatives. The multifunctional polyethylene glycol derivatives, flexible polymers in terms of the branch structures, are easy to control and have wide applications.

However, azide alkyne cycloaddition reaction was used to synthesize antimicrobial peptide containing a carboxy amidated C-terminus (HSP1) and related physicochemical properties of the synthesized peptide such as DLS and Zeta potential were evaluated [6]. Increased fungicidal activity of the glycotriazole-peptides could be related to the presence of the triazole rings. Also, the catalytic activity of tricationic gold complex had been evaluated in the intramolecular hydroacylation of a terminal alkyne [7]. Previously, propargyl acetate derivatives and the synthesized compounds were evaluated for antituberculotic activity [8] and minimum inhibitory concentration (MIC) of the drugs was evaluated [9,10].

Epilogue

There is essential need in organometallic chemistry to synthesize new compounds such as antifungal biomaterials and cluster−alkyne complexes, for example alkyne coordinated Iridium cluster, to use in pharmaceutical industries. In our point of view, synthesis and characterization of new alkyne derivatives as antifungal agents could be carried out qualitatively and quantitatively by analytical methods such as UV-vis and 1H NMR spectroscopies [11].

References

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