Synthesis New Amid of Carboxylic Acids and Antimicrobial Activity – I
GH Torosyan*and NR Hovhannisyan
National polytechnic university of Armenia, Yerevan
Submission: May 24, 2018; Published: May 28, 2018
*Corresponding author: GH Torosyan, National polytechnic university of Armenia, Armenia, Yerevan, Email: [email protected]
How to cite this article: GH Torosyan, NR Hovhannisyan.Synthesis New Amid of Carboxylic Acids and Antimicrobial Activity – I. Organic & Medicinal Chem IJ. 2018; 6(5):
555701. DOI: 10.19080/OMCIJ.2018.07.555701
The amides of carboxylic acids are important organic compounds and have a wide range of applications. It`s known them wide range biological functionalities , they occur in the main chain of a proteins and in synthetic polyamide materials. Low molecular weight amide as formamide and dimethylformamide are common solvent . Amide bond formation is a fundamentally important reaction in organic synthesis . A convenient method for the formation of carboxamides from carboxylic acids and primary amines in the presence of molecular sieves is described. This process is very chemoselective [3,4].
N-allyl-N-pentadien-2,4-yl(furfuryl) amine and acetic acid chloride were reacted intensively over 6hour in in dioxane solution (with 2 molar ratio of alkaline solution). Additionally, the reaction mixture was added the water, extracted by chloroform, dried on MgSO4.
Antmicrobial properties of amid are studied by serial extraction in vitro method. It had been used as indicative microorganisms:
a) Staphylococeus aureeus # 209 “P”, as a stable, bacterial bacteria group;
b) Escherichia coli serotype 0 III B: 4, as is the fastest bacterial from families of intestinal microorganisms. The test was cultured on MPA and MPB with pH = 7,2-7,4. The acaric bacteria were used in the stages of the second genetics.