Literature Review of Analytical Methods for Determination of Triamcinolone Acetonide and Benzyl Alcohol
Yara Elkady, Sobhy M El-Adl, Mohamed Baraka and Mahmoud M Sebaiy*
Department of Medicinal Chemistry, Zagazig University, Egypt
Submission:August 31, 2020; Published: September 08, 2020
*Corresponding author: Mahmoud M Sebaiy, Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
How to cite this article: Yara E, Sobhy M E, Mohamed B, Mahmoud M S. Literature Review of Analytical Methods for Determination of Triamcinolone Acetonide and Benzyl Alcohol. Nov Appro Drug Des Dev. 2020; 5(3): 555663. DOI: 10.19080/NAPDD.2020.05.555663
Abstract
In this review article, we will introduce all reported methods that have been developed for determination of triamcinolone acetonide and benzyl alcohol in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of our cited drugs.
Keywords: Drugs; Benzyl alcohol; Acetonitrile; phosphoric acid; Benzoic acid
Metods for Analysis of Triamcinolone
Chromatographic methods:
HPLC methods:
a)Spectrofluorimetric methods: The methodology depends on the fluorescence of creation of triamcinolone acetonide oxidized by concentrated sulfuric corrosive. The impact of H2SO4, β-cyclodextrin (β-CD), dissolvable and cetyltrimethylammonium bromide (CTMAB) were talked about. Furthermore, two diagnostic frameworks were set up. One is CTMAB framework, the straight range is 0-4.6×10-6 mol/L, and as far as possible is 3.59×10−8 mol/L (Table 1-3). The other is β-CD and ethanol framework, the straight range is 0–2.3×10−6 mol/L and as far as possible is 1.91×10−8 mol/L. The selectivity of examination, the investigative figures of improvement, and the exactness of the technique are exhibited with the assurance of triamcinolone acetonide in pharmaceutical arrangements [18].
b)Luminescence methods: A rapid lateral flow immunochromatographic measure (ICA) was created for the quantitative identification of TAM utilizing a test dependent on up conversion radiance nanoparticles. Lanthanide-doped up conversion nanoparticles (UCNPs) were incorporated in a framework involving water and ethylene glycol, and a silicon dioxide layer was secured at the carboxyl site. A coupling site assurance procedure was utilized to diminish the foundation sign of UCNPs-ICA. Utilizing dexamethasone subsidiary as a covering antigen, the ideal UCNPs-ICA displays great unique straight location for TAM in the range 1.0-100 ng mL-1 with a middle inhibitory grouping of 9.8 ng mL-1. As far as possible for TAM in a corrective example are 20 μg kg-1. The pretreatment samples need dilution with water, suggesting the assay can quantitate TAM on-site using a portable upconversion luminescence reader with a cumulative analysis time of only 10 min. [19] (Table 4-6).
Methods for Analysis of Benzyl Alcohol
Chromatographic methods:
HPLC methods:
Conclusion
This literature review represents an up to date survey about all reported methods that have been developed for determination of triamcinolone acetonide and benzyl alcohol in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples such as liquid chromatography, spectrophotometry, spectroflourimetry, etc.
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