High incidence of death rate among cancer patients in addition to the mental depression and reduction in the Immune strength had laid an immediate urge towards the palliation therapy contrary to the regular cancer treatment. The objective of the work is using the mistletoe extract in cancer palliation. Randomized population of cancer victims is selected for the study wherein the administration of mistletoe extract ranging from 0.02mg to 20mg over a period of 6 months in an ascending dosage given subcutaneous. Pain, Anorexia, Insomnia, Weight loss, Low immunity, Weakness like symptoms were analysed after the palliation treatment. Improved levels were reported for all the symptoms. Cancer Palliation targeting the above symptoms was successful with the use of mistletoe extract. Palliation is the best method of treating the victims of end stage cancer. The study also proved the soothing action of mistletoe extract and its importance in the palliation of end stage cancer patients.
In the end stage cancer patients where in the cure is an obligate failure necessitates the palliation approach which focuses on creating an easy and comfort life to the patient rather than treating them as an experimental model for the research . Palliation approach would help in the quality improvement of the end stage life whose recovery cannot be expected. Various palliation therapies have been developed which can mentally support the well-being of the victim. Massage is also proved to be the better approach in some of the diseases. The current work is an approach where in the use of mistletoe extract in various concentrations has been used towards reaching the goal . Several studies provide the beneficial effects of the mistletoe and its palliation effect. The present work aimed towards analysing the palliation of cancer symptoms like Pain, Anorexia and Insomnia etc. Whose treatment would bring back the Psychological strength and general immunity of the patient? The study is based on the use of a treatment methodology which emphasizes on maintaining the patients mental condition and peace by controlling or totally preventing the side effects. Apart from its pathogenic activity, the new scientific era has revealed its importance in the treatment of cancer this breakthrough in the history of cancer therapy. There are very few side effects which may be caused by the use of mistletoe extract [3-8]. The inherent nature of this extract can provide a soothing effect for the patients thereby maintaining a pleasant environment
for the patient. Palliation therapy focuses on the psychological effect of the patient rather than the metabolic change.
Mistletoe extract in its purified and sterile form in various strength are administered subcutaneously to control the symptoms of cancer. The extract has several biochemical and metabolic effects which are directly responsible for controlling the adverse effects of cancer [9-12]. The extract is known to have immuno-modulation wherein it activates the Macrophages and phagocyte cells and induces apoptosis thereby controlling the cell number . It is also known to cause dose dependent cytotoxicity thereby regulating the cell count in cancer condition. Animal experiments also proved that the extract is known for its inhibition of tumours and metastasis . There are also first indications of inhibition of tumour angiogenesis.
The author being a medical doctor has good direct access for the patients. The patients diagnosed with the cancer and qualifying all the eligibility criteria were selected for the study. All the study population are from Rishikesh hospital and Research Centre, Nasik, Maharashtra, India. A written consent was undertaken from all the patients for the current study. A questionnaire was also attended by the study population to evaluate the other physiological and psychological changes after
83 individuals in their last i.e. 4th stage of cancer who had
already received the conventional treatment methodologies and
exhibiting marked side effects were selected for the study. The
major criteria considered while selecting is that the patients who
have no chances of treatment and recovery so as to direct them
towards good life rather than complete life. Patients who were
still on their conventional treatment with no side effects were
excluded from the study.
All the study population were regularly monitored for
the physical and Psychological changes during the entire
regimen. The mistletoe extracts were used in the entire study.
Subcutaneous injections of the extract were delivered every
alternative day to all the 83 population in an ascending dosage.
The concentration of the extract was started from 0.02mg and
was gradually increased to a range of 0.2mg, 2mg and finally to
a maximum range of 20mg for a period of 6 months (8 ampoules
of each strength was used before escalating to the next strength).
All the Physical and Psychological changes in the patients were
recorded with at most care. Other physiological parameters like
pain, insomnia, anorexia, weight loss, weakness and decreased
immunity were also monitored and recorded at regular intervals.
The parameters tested at each stage of the regimen include
CBC, ESR, LFT, RFT, CRP, Specific TUMOR MARKERS and CT
SCAN all of which showed remarkable improvement (including
normal WBC count). The Complete Blood Count was analysed at
regular intervals to detect the changes in the total cell count and
the cancer progression rate. This was followed by Erythrocyte
Sedimentation Rate detection that could provide an insight to
the degree of cancer progression. Elevated levels of ESR indicate
the adverse situations and inflammation in the disease. Liver
function tests and renal function tests would act as an index to the
condition of the kidneys and liver in cancer condition. C Reactive
Protein is elevated in the diseased conditions. The estimation of
CRP levels in the blood can be a method of analysing the status
of the disease. During the complete palliation period the CRP
levels have been recorded to understand the effectiveness of
the therapy on the degree of disease. Specific Tumour Markers
are one of the out of track diagnostic approach, wherein the
molecular level based accurate detection is made. The diseased
condition is declared based in the presence of specific markers in
the DNA. This is the current day diagnostic approach used for the
final determination of diseased condition. The marker analysis
is performed to identify the degree of cancer in the study
population. CT scan is also employed for the disease condition
analysis. The above detection criteria have been employed in the
complete work to analyse the degree of effectiveness in using
Mistletoe extract in the palliation of cancer condition.
83 Random populations affected with cancer and suffering
in their 4th stage are chosen. All the patients had marked
side effects due to the regular treatment methodologies. The
study aimed to provide these patients a better quality of the
remaining life rather than prolonging their existing life span.
All the 83 individuals were administered with the mistletoe
extract from a dosage range of 0.02mg to 20mg in an ascending
order for a period of 6 months. All the results were recorded in
terms of parameters like CBC, CRP, LFT, RFT etc. Additionally
the symptoms like pain, anorexia, and insomnia etc were also
analysed in regular intervals. Table 1 symptoms like pain and
anorexia were nearly eliminated among the patients; however
the rate of improvement varied among the individuals. Insomnia
was greatly affected as more than 70 individuals reported a
good sleep time during and after the treatment regimen. The
physical stamina also showed an improved status in addition to
the mental strength. The improvement was at a great extent that
the use of analgesics for pain relief was totally stopped after the
therapy in some cases. There was a great improvement in the
body mass and a reduced tumour cell weight. Cell Apoptosis rate
was found to be increased due to the administration of mistletoe
extract. The study was successful for 64 individuals among the
total 83 considered.
The current work was targeted to the end stage 4th degree
cancer patients who have no chances of recovery and had high
and marked side effects due to the regular cancer treatment
methodologies. The study aimed to provide a better quality
of life to the end stage patients rather than prolonging their
life mechanically. The major point of concern in treating these
patients is their Psychological condition and mental peace.
Palliation of caner is the best option for the doctors at this stage
of life. The study uses Mistletoe Extract in reaching its goal. The
extract was subcutaneously administered for a study population
of 83 in an ascending order starting from 0.02mg to 20mg for a
period of 6 months.
All the parameters like CBC, LFT, RFT, ESR, CRP etc. were
recorded at regular intervals. Apart from the biochemical
parameters, physiological symptoms were also taken care
of. The most treating symptoms like Weight loss, Weakness,
Decreased Immune strength, Pain, Anorexia, Insomnia were
focussed during the entire treatment protocol. The results
were very much satisfactory for a population of 64 to a total
of 83. All the biochemical parameters mentioned indicated an
improved life quality during and after the treatment. The CBC
was decreased due to an increased level of apoptosis, Insomnia
was nearly eliminated and pain was completely cured to such an
extent that the use of analgesics was completely stopped in some
cases. The measurement of tumour markers showed a decreased
values and improved body weight was reported. To conclude
the treatment regimen using mistletoe in the palliation of end
stage cancer was highly successful at a rate of 77% in not only
improving the biochemical and metabolic status of the patient
but also in bringing back the psychological status of the patient.
The above study showed a success rate of 77% while the others
still had adverse reaction which was out of control towards this
particular treatment protocol.