Case Report: A Rare Case of Tumor:
A Metastatic GIST
Kalaji Manhal1*, Terryn François Xavier1, Henry Paulina2, Petit Bénédicte3 and Mansvelt Baudouin1
1Unité de chirurgie digestive, Hôpital de Jolimont, Belgium
2Service anatomo-pathologique, Hôpital de Jolimont, Belgium
3Service d’oncologie, Hôpital de Jolimont, Belgium
Submission: August 14, 2019; Published: August 27, 2019
*Corresponding author: Kalaji Manhal, Unité de chirurgie digestive, Hôpital de Jolimont, Rue Louis Franson 2, 7100 Haine Saint-Pierre, Belgium
How to cite this article: Kalaji Manhal, Terryn François Xavier, Henry Paulina, Petit Bénédicte, Mansvelt Baudouin. Case Report: A Rare Case of
Tumor: A Metastatic GIST. JOJ Case Stud. 2019; 10(3): 555789. DOI: 10.19080/JOJCS.2018.09.555789.
Gastrointestinal Stromal Tumors “GIST” is a rare form of digestive tract cancer with an estimated incidence of 15 cases per million population with an average age of 60 years. The surgical methods remain the main form of treatment and the only curative one. This case study is about a 5-year-old patient who presented non-specific abdominal pain and impaired general state. The CT-scan showed a voluminous abdominal mass located in the stomach as well as two liver metastases. We decided to perform a surgical biopsy of the gastric mass in order to identify its type. The anatomopathological analysis concluded in a Gastrointestinal Stromal Tumor, probably of gastric origin. In this context, we decided to initiate an Imatinib treatment: 400mg a day per os in one take. The patient initially responded very well to the treatment with a decrease of the size of the gastric tumor but, after 4 years, the mass started to further increase in volume.
After multidisciplinary discussion and involvement of the patient, surgical resection was agreed upon. No lymph node resection was done since lymph node metastases are rare. We performed a total gastrectomy with complete monobloc surgical resection of the tumor as well as a metastasectomy of the two liver lesions, an ablation of lesion on the ligamentum teres hepatis and hepatic hilum and finally a preventive cholecystectomy
Keywords: GastroIntestinal Stromal Tumors (GIST); Imatinib, Surgery
Although gastrointestinal stromal tumors (GIST) are the most frequent sarcomas, they have been very poorly studied up until twenty years ago .
These tumors are the most common mesenchymal tumors of the gastrointestinal tract but still represent less than 1% of all gastrointestinal tumors . GIST is a group of mesenchymal tumors that derive from interstitial cells of Cajal and which develop from the Muscularis propria. They may be acquired or genetic .
Imatinib has revolutionized the management of locally advanced and metastatic GIST. However, the surgical methods remain the main form of treatment and the only curative one . This case report presents a metastatic gastric gastrointestinal stromal tumor recently removed in a 65-year-old male patient, the outcome and a literature review of the pathological identification, sites of origin, prognosis and treatment.
A 65-year-old male patient with no significant medical history other than type 2 diabetes consulting for non-specific abdominal pain associated with a 2kg weight loss and an impaired general state, which wasn’t investigated. Family history was noncontributory.
The abdomen was soft and painless during physical examination.
A contrast-enhanced thoraco-andominal CT-scan showed a voluminous abdominal mass measuring 25 x 20cm located in the stomach as well as two liver lesions. No pulmonary lesions were found. After a multidisciplinary discussion, we decided to proceed to a surgical biopsy of the gastric mass in order to identify the etiology. The anatomopathological analysis revealed a Gastrointestinal Stromal Tumor, probably of gastric origin. We decided to start a treatment with Imatinib (Glivec) 400mg . The medical treatment with Imatinib worked well at first but a
further increase in volume of the mass, but not the metastases,
was discovered after four years. After a new multidisciplinary
discussion, given the resectability of the lesion, it was decided to
perform a surgical “en bloc” resection of the tumor .
Until 1998, gastrointestinal stromal tumors remained largely
unknown. In the beginning of the 80’s, the generalization of
immunohistochemistry techniques allowed us to take enabled a
big step in the diagnosis, but also in the treatment of these tumors
since they are characterized by a very frequent expression of KIT
(CD117), whose expression is specific to the interstitial cells of
Cajal. GISTs are slightly more prevalent in male patients, with an
average diagnosis age of 60 years [7,8].
Our patient suffered from abdominal discomfort and
abdominal bloating. After further questioning, he confirmed a
feeling of early satiety. He denied any other symptoms.
If surgery is the standard procedure for all GIST of small
intestine or rectum it is not the case for gastric GIST. The
treatment strategy in these cases is affected by several factors:
the size of the tumor, its location, its adhesions to nearby
structures and presence or absence of metastasis [1,9] (Figure
Some studies have suggested the high frequency of small
gastric GIST (<10mm in diameter) in adults after 50 years of age.
The evolution of those tumors is not certain, and they could even
regress in the future. Other studies seem to show that the risk
of malignancy in GIST of the stomach is very low or inexistent
when their diameter is smaller than 2cm [10-12].
Thus, for gastric GISTs of less than 2cm, the choice between
clinical surveillance and surgery will be based on symptoms
(minor at this size), patients’ general condition and location
of the lesion in the stomach, facilitating resection or not.
Endoscopic excision may be a treatment option for gastric GISTs
of this size. Some Asian teams use this technique, which remains
less invasive. It can also be combined with laparoscopy, but its
efficiency remain uncertain. For non-metastatic gastric GIST
greater than 2cm, complete surgical excision is the standard
procedure with or without prior Imatinib treatment [13,14].
Our case is different from all these situations since it is a
metastatic gastric GIST. The studies show that in responding
or stable patients using Imatinib and potentially accessible for
an R0 resection, the role of surgery remains to be clarified. Its
feasibility has been shown, but its impact on survival hasn’t
yet been established. Two randomized trials (continuation of
Imatinib versus surgery and continuation of Imatinib) were
suspended due to slow recruitment. The Chinese trial, which
included only 41 patients, did however show a non-significant
trend in favor of the “surgery” group .
Our institution believes surgery remains the best solution
and the only curative one if R0 is possible, even in metastatic
cases . We therefore proceeded to a total gastrectomy with
complete monobloc surgical resection of the tumor as well
as a metastasectomy of the two liver lesions, a removal of the
ligamentum teres hepatis and hepatic hilum metastases and,
finally, a preventive cholecystectomy. No lymphadenectomy
was performed since lymph node metastases are rare, even in
advances cases, and all the forty-eight lymph nodes associated
to the surgical piece showed no anatomopathological signs
of malignancy. At six months postoperatively, an abdominal
contrast-enhanced CT scan showed no sign of resurgence.
Even though this is an isolated case, it might be worth
thinking about the management of stable metastatic GIST under
Imatinib. A new randomized study could, of course, allow a
big step in the management of these tumors. Unfortunately,
recruitment is a main limitation since these cases are rare.