Maternal Thyroid Disorders and Developing Metabolic Syndrome
Ahmed RG*
Zoology Department, Beni-Suef University, Egypt
Submission: February 02, 2018; Published: March 26, 2018
*Corresponding author: Ahmed RG, Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt, Tel: 002-010-91471828; Email: ahmedragab08@gmail.com
How to cite this article: Ahmed R. Maternal Thyroid Disorders and Developing Metabolic Syndrome. J Endocrinol Thyroid Res . 2018; 3(2): 555609. DOI: 10.19080/JETR.2018.03.555609
Letter to Editor
The normal progress of fetuses and neonates is dependent on the normal supply of maternal thyroid hormones (THs) [165], in particular the body weight, blood pressure, and glucose and lipid metabolism [66]. On the other hand, thyroid disorders and metabolic syndrome are very public endocrine dysfunctions [67-73]. Any disturbances in the levels of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) can vary the glucose metabolism and cause insulin resistance, abdominal obesity, dyslipidemia, hypertension [72,74,-77] and mortality or morbidity [78,79]. These disorders can increase the risk of metabolic syndrome [81]. As well, signs and symptoms of the metabolic syndrome might be increased in the subclinical hypothyroid [79] in particular in the elderly [72]. In this regard it is essential to notice that cross-sectional examinations recorded that the metabolic syndrome and its signs such as elevated triglycerides level, high serum cholesterol level, and high blood pressure are closely associated with the subclinical hypothyroidism [81-86]. However, other studies did not find any association between the metabolic syndrome and subclinical hypothyroidism [84,85,88]. The percentage index of the metabolic syndrome is 20% to 30% in western countries [89-92] and 10% to 21% in China [93]. Several investigators reported that there is a positive association between the elevation in the level of thyroid-stimulating hormone (TSH) and the development of metabolic syndrome especially in the adolescents [94,92,95]. The elevation in TSH level during obesity might be attributed to the elevation in the concentration of leptin, inflammatory factors, and autoimmune status [96]. More importantly, Eckel et al. [75] elucidated that the metabolic syndrome can increase the risk of cardiovascular disease three times and the risk of type 2 diabetes five times [97].
Conclusion
Maternal hypothyroidism may be related to developing metabolic syndrome in relative to the insulin resistance, cardiovascular diseases, hypertension, mortality and morbidity. However, whether such an association occurs in juveniles remains unidentified. Future studies on the relation between the maternal thyroid dysfunction and the development of the metabolic syndrome are required. Also, additional prospective examinations are wanted to detect whether the treatment of elevated TSH may diminish the signs and symptoms of the metabolic syndrome.
Conflict of Interest
The author declares that no competing financial interests exist.
References
- El-bakry AM, El-Ghareeb AW, Ahmed RG (2010) Comparative study of the effects of experimentally-induced hypothyroidism and hyperthyroidism in some brain regions in albino rats. Int J Dev Neurosci 28(5): 371-389.
- Ahmed RG (2011) Perinatal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exposure alters developmental neuroendocrine system. Food Chem Toxicology 49(6): 1276-1284.
- Ahmed RG (2012a) Maternal-newborn thyroid dysfunction. In: Ahmed RG (Ed.), The Developmental Neuroendocrinology LAP LAMBERT Academic Publishing GmbH & Co KG, Germany, pp. 1-369.
- Ahmed RG (2012b) Maternal-fetal thyroid interactions. In: Agrawal NK (Ed.), Thyroid Hormone. In Tech Open Access Publisher, Chapter 5, pp. 125-156.
- Ahmed RG (2013) Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction. J Endocrinol 219(3): 205-215.
- Ahmed RG (2014) Editorial: Do PCBs modify the thyroid-adipokine axis during development? Annals Thyroid Res 1(1): 11-12.
- Ahmed RG (2015a) Chapter 1: Hypothyroidism and brain development. In advances in hypothyroidism treatment. Avid Science Borsigstr, Berlin, Germany.
- Ahmed RG (2015b) Hypothyroidism and brain developmental players. Thyroid Research J 8(2): 1-12.
- Ahmed RG (2015c) Editorials and Commentary: Maternofetal thyroid action and brain development. J of Advances in Biology 7(1): 12071213.
- Ahmed RG (2016a) Gestational dexamethasone alters fetal neuroendocrine axis. Toxicol Lett 258: 46-54.
- Ahmed RG (2016b) Neonatal polychlorinated biphenyls-induced endocrine dysfunction. Ann Thyroid Res 2(1): 34-35.
- Ahmed RG (2016c) Maternal iodine deficiency and brain disorders. Endocrinol Metab Syndr 5: 223.
- Ahmed RG (2016d) Maternal bisphenol A alters fetal endocrine system: Thyroid adipokine dysfunction. Food Chem Toxicology 95: 168-174.
- Ahmed RG (2017a) Developmental thyroid diseases and GABAergic dysfunction. EC Neurology 8(1): 02-04.
- Ahmed RG (2017b) Hyperthyroidism and developmental dysfunction. Arch Med 9(4): 6.
- Ahmed RG (2017c) Anti-thyroid drugs may be at higher risk for perinatal thyroid disease. EC Pharmacology and Toxicology 4(4): 140142.
- Ahmed RG (2017d) Perinatal hypothyroidism and cytoskeleton dysfunction. Endocrinol Metab Syndr 6: 271.
- Ahmed RG (2017e) Developmental thyroid diseases and monoaminergic dysfunction. Advances in Applied Science Research 8(3): 01-10.
- Ahmed RG (2017f) Hypothyroidism and brain development. J. Anim Res Nutr. 2(2), 13.
- Ahmed RG (2017g) Antiepileptic drugs and developmental neuroendocrine dysfunction: Every why has A Wherefore. Arch Med 9(6): 2.
- Ahmed RG (2017h) Gestational prooxidant-antioxidant imbalance may be at higher risk for postpartum thyroid disease. Endocrinol Metab Syndr 6: 279.
- Ahmed RG (2017i) Synergistic actions of thyroid-adipokines axis during development. Endocrinol Metab Syndr 6: 280.
- Ahmed RG (2017j) Thyroid-insulin dysfunction during development. International Journal of Research Studies in Zoology 3(4): 73-75.
- Ahmed RG (2017k) Developmental thyroid diseases and cholinergic imbalance. International Journal of Research Studies in Zoology 3(4): 70-72.
- Ahmed RG (2017l) Thyroid diseases and developmental adenosinergic imbalance. Int J Clin Endocrinol 1(2): 053-055.
- Ahmed RG (2017m) Maternal anticancer drugs and fetal neuroendocrine dysfunction in experimental animals. Endocrinol Metab Syndr 6: 281.
- Ahmed RG (2017n) Letter: Gestational dexamethasone may be at higher risk for thyroid disease developing peripartum. Open Journal Of Biomedical & Life Sciences (Ojbili) 3(2): 01-06.
- Ahmed RG (2017o) Deiodinases and developmental hypothyroidism. EC Nutrition 11(5): 183-185.
- Ahmed RG (2017p) Maternofetal thyroid hormones and risk of diabetes. Int J of Res Studies in Medical and Health Sciences 2(10): 1821.
- Ahmed RG (2017r) Association between hypothyroidism and renal dysfunctions. International Journal of Research Studies in Medical and Health Sciences 2(11): 1-4.
- Ahmed RG (2017s) Maternal hypothyroidism and lung dysfunction. International Journal of Research Studies in Medical and Health Sciences 2(11): 8-11.
- Ahmed RG (2017t) Endocrine disruptors; possible mechanisms for inducing developmental disorders. International journal of basic science in medicine (IJBSM) 2(4): 157-160.
- Ahmed RG (2017u) Maternal thyroid hormones trajectories and neonatal behavioral disorders. ARC Journal of Diabetes and Endocrinology 3(2): 18-21.
- Ahmed RG (2017v) Maternal thyroid dysfunction and neonatal cardiac disorders. Insights Biol Med 1: 092-096.
- Ahmed RG (2018a) Maternal hypothyroidism and neonatal testicular dysfunction. International Journal of Research Studies in Medical and Health Sciences 3(1): 8-12.
- Ahmed RG (2018b) Maternal hypothyroidism and neonatal depression: Current perspective. International Journal of Research Studies in Zoology 4(1): 6-10.
- Ahmed RG (2018c) Non-genomic actions of thyroid hormones during development. App Clin Pharmacol Toxicol: ACPT-108.
- Ahmed RG (2018d) Maternal thyroid function and placental hemodynamics. ARC Journal of Animal and Veterinary Sciences 4(1): 9-13.
- Ahmed RG (2018e) Interactions between thyroid and growth factors during development. ARC Journal of Diabetes and Endocrinology 4(1):1-4.
- Ahmed RG (2018f) Maternal thyroid hormones and neonatal appetite. ARC Journal of Nutrition and Growth 4(1): 18-22.
- Ahmed RG (2018g) Genomic actions of thyroid hormones during development. ARC Journal of Diabetes and Endocrinology 4(1): 5-8.
- Ahmed RG (2018h) Dysfunction of maternal thyroid hormones and psychiatric symptoms. American Research Journal of Endocrinology 2(1): 1-6.
- Ahmed RG (2018i) Is there a connection between maternal hypothyroidism and developing autism spectrum disorders? ARC Journal of Neuroscience 3(1): 5-8.
- Ahmed RG (2018j) Maternal thyroid dysfunctions and neonatal bone maldevelopment. American Research Journal of Endocrinology.
- Ahmed RG (2018k) Maternal thyroid disorders and risk of neonatal seizure: Current perspective. ARC Journal of Neuroscience 3(1): 21-25.
- Ahmed RG (2018l) Gestational dioxin acts as developing neuroendocrine-disruptor. EC Pharmacology and Toxicology 6: 3.
- Ahmed OM, Ahmed RG, El-Gareib AW, El-Bakry AM, Abd El-Tawaba SM (2012) Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II-The developmental pattern of neurons in relation to oxidative stress and antioxidant defense system. Int J Dev Neurosci 30: 517-537.
- Ahmed OM, El-Gareib AW, El-bakry AM, Abd El-Tawab SM, Ahmed RG (2008) Thyroid hormones states and brain development interactions. Int J Dev Neurosci 26(2): 147-209.
- Ahmed OM, Abd El-Tawab SM, Ahmed RG (2010) Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I- The development of the thyroid hormones-neurotransmitters and adenosinergic system interactions. Int J Dev Neurosci 28(6): 437-454.
- Ahmed OM, Ahmed RG (2012) Hypothyroidism. In: Dr. D. Springer (Ed.), A New Look At Hypothyroidism. In Tech Open Access Publisher, Chapter 1, pp. 1-20.
- Ahmed RG, Davis PJ, Davis FB, De Vito P, Farias RN, et al. (2013a) Nongenomic actions of thyroid hormones: from basic research to clinical applications. An update. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 13(1): 46-59.
- Ahmed RG, Incerpi S, Ahmed F, Gaber A (2013b) The developmental and physiological interactions between free radicals and antioxidant: Effect of environmental pollutants. J of Natural Sci Res 3(13): 74-110.
- Ahmed RG, El-Gareib AW, Incerpi S (2014) Lactating PTU exposure:II- Altets thyroid-axis and prooxidant-antioxidant balance in neonatal cerebellum. Int Res J of Natural Sciences 2(1): 1-20.
- Ahmed RG, Abdel-Latif M, Ahmed F (2015a) Protective effects of GM- CSF in experimental neonatal hypothyroidism. Int Immunopharmacol 29(2): 538-543.
- Ahmed RG, Abdel-Latif M, Mahdi E, El-Nesr K (2015b) Immune stimulation improves endocrine and neural fetal outcomes in a model of maternofetal thyrotoxicosis. Int Immunopharmacol 29(2): 714-721.
- Ahmed RG, El-Gareib AW, Shaker HM (2018a) Gestational 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure disrupts fetoplacental unit: Fetal thyroid-cytokines dysfunction. Life Sci 192: 213-220.
- Ahmed RG, Walaa GH, Asmaa FS (2018b) Suppressive effects of neonatal bisphenol A on the neuroendocrine system. Toxicology and Industrial Health Journal (in press).
- Ahmed RG, Incerpi S (2013) Gestational doxorubicin alters fetal thyroid-brain axis. Int J Devl Neuroscience 31(2): 96-104.
- Van Herck SLJ, Geysens S, Bald E, Chwatko G, Delezie E, et al. (2013) Maternal transfer of methimazole and effects on thyroid hormone availability in embryonic tissues. Endocrinol 218(1): 105-115.
- Ahmed RG, El-Gareib AW (2014) Lactating PTU exposure: I- Alters thyroid-neural axis in neonatal cerebellum. Eur J of Biol and Medical Sci Res 2(1): 1-16.
- Incerpi S, Hsieh MT, Lin HY, Cheng GY, De Vito P, et al. (2014) Thyroid hormone inhibition in L6 myoblasts of IGF-I-mediated glucose uptake and proliferation: new roles for integrin av|33. Am J Physiol Cell Physiol 307(2): C150-C161.
- Candelotti E, De Vito P, Ahmed RG, Luly P, Davis PJ, et al. (2015) Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses. Immun Endoc & Metab Agents in Med Chem 15(1): 71-85.
- De Vito P, Candelotti E, Ahmed RG, Luly P, Davis PJ, et al. (2015) Role of thyroid hormones in insulin resistance and diabetes. Immun Endoc & Metab Agents in Med Chem 15: 86-93.
- El-Ghareeb AA, El-Bakry AM, Ahmed RG, Gaber A (2016) Effects of zinc supplementation in neonatal hypothyroidism and cerebellar distortion induced by maternal carbimazole. Asian Journal of Applied Sciences 4(04): 1030-1040.
- Ahmed RG, El-Gareib AW (2017) Maternal carbamazepine alters fetal neuroendocrine-cytokines axis. Toxicology 382: 59-66.
- Mehran L, Amouzegar A, Rahimabad PK, Tohidi M, Tahmasebinejad Z, et al. (2017) Thyroid function and metabolic syndrome: A population- based thyroid study. Horm Metab Res 49(3): 192-200.
- Maratou E, Hadjidakis DJ, Peppa M, Alevizaki M, Tsegka K, et al. (2010) Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism. Eur J Endocrinol 163(4): 625-630.
- Santi A, Duarte MM, Moresco RN, Menezes C, Bagatini MD, et al. (2010) Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism. Clin Chem Lab Med 48(11): 1635-1639.
- Zhu X, Cheng SY (2010) New insights into regulation of lipid metabolism by thyroid hormone. Curr Opin Endocrinol Diabetes Obes 17(5): 408413.
- Azizi F, Amouzegar A, Delshad H, Tohidi M, Mehran L, et al. (2013) Natural course of thyroid disease profile in a population in nutrition transition: Tehran Thyroid Study. Arch Iran Med 16(7): 418-423.
- Heima NE, Eekhoff EM, Oosterwerff MM, Lips PT, van Schoor NM, et al. (2013) Thyroid function and the metabolic syndrome in older persons: a population-based study. Eur J Endocrinol 168(1): 59-65.
- Iwen KA, Schroder E, Brabant G (2013) Thyroid hormones and the metabolic syndrome. Eur Thyroid 2(2): 83-92.
- Amouzegar A, Kazemian E, Gharibzadeh S, Mehran L, Tohidi M, et al. (2015) Association between thyroid hormones, thyroid antibodies and insulin resistance in euthyroid individuals: A population-based cohort. Diabetes Metab 41: 480-488.
- Ferrannini E, Haffner SM, Mitchell BD, Stern MP (1991) Hyperinsulinaemia: The key feature of a cardiovascular and metabolic syndrome. Diabetologia 34(6): 416-422.
- Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365(9468): 1415-1428.
- Dimitriadis G, Mitrou P, Lambadiari V, Boutati E, Maratou E, et al. (2006) Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab 91(12): 4930-4937.
- Waring AC, Rodondi N, Harrison S, Kanaya AM, Simonsick EM, et al. (2012) Thyroid function and prevalent and incident metabolic syndrome in older adults: the Health, Ageing and Body Composition Study. Clin Endocrinol (Oxf) 76(6): 911-918.
- Ford ES (2005) Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 28(7): 1769-1778.
- Thvilum M, Brandt F, Almind D, Christensen K, Hegedus L, et al.(2013) Excess mortality in patients diagnosed with hypothyroidism: a nationwide cohort study of singletons and twins. J Clin Endocrinol Metab 98(3): 1069-1075.
- Liu YY, Brent GA (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol Metab 21(3): 166-173.
- Meigs JB (2000) Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am J Epidemiol 152(10): 908-911.
- Oparil S, Zaman MA, Calhoun DA (2003) Pathogenesis of hypertension. Annals of internal medicine 139(9): 761-776.
- Fernandez-Real JM, Lopez-Bermejo A, Castro A, Casamitjana R, Ricart W (2006) Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects. J Clin Endocrinol Metab 91(9): 3337-3343.
- Roos A, Bakker SJ, Links TP, Gans RO, Wolffenbuttel BH (2007) Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. J Clin Endocrinol Metab 92(2): 491-496.
- Stabouli S, Papakatsika S, Kotsis V (2010) Hypothyroidism and hypertension. Expert review of cardiovascular therapy 8(11): 15591565.
- Chang CH, Yeh YiC, Caffrey JL, Shih SR, Chuang LM, et al. (2017) Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism - A Cohort Study. Sci Rep 7(1): 6754.
- Kim BJ, Kim TY, Koh JM, Kim HK, Park JY, et al. (2009) Relationship between serum free T4 (FT4) levels and metabolic syndrome (MS) and its components in healthy euthyroid subjects. Clin Endocrinol (Oxf) 70(1): 152-160.
- Park HT, Cho GJ, Ahn KH, Shin JH, Hong SC, et al. (2009) Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women. Maturitas 62(3): 301-305.
- Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, et al. (2003) Metabolic syndrome:epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study. Int J Obes Relat Metab Disord 27(10): 1283-1289.
- Meigs JB, Wilson PW, Nathan DM, D Agostino RB, Williams K, et al. (2003) Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies. Diabetes 52(8): 2160-2167.
- Salaroli LB, Barbosa GC, Mill JG, Molina MC (2007) Prevalence of metabolic syndrome in population-based study, Vitoria, ES-Brazil. Arq Bras Endocrinol Metabol 51(7): 1143-1152.
- Lai Y, Wang J, Jiang F, Wang B, Chen Y, et al. (2011) The relationship between serum thyrotropin and components of metabolic syndrome. Endocrine J 58(1): 23-30.
- Jia W (2006) Metabolic syndrome and clinical characteristics of Chinese People. Chin J Endocrinol Metab 22(3): 181-186 (in Chinese).
- Ayturk S, Gursoy A, Kut A, Anil C, Nar A, et al. (2009) Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area. Eur J of Endocrinol 161(4): 599-605.
- Zhang J, Jiang R, Li L, Li P, Li X, et al. (2014) Serum thyrotropin is positively correlated with the metabolic syndrome components of obesity and dyslipidemia in Chinese adolescents. Int J Endocrinol 289503.
- Reinehr T (2011) Thyroid function in the nutritionally obese child and adolescent. Current Opinion in Pediatrics 23(4): 415-420.
- Mehran L, Amouzegar A, Tohidi M, Moayedi M, Azizi F (2014) Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects. Thyroid 24(11): 1566-1574.