International journal of Pulmonary & Respiratory Sciences

Case Report

Submadibular Abscess with Velopharyngeal Insufficiency: Unusual Clinical Presentation of Tuberculosis

Swati Tandon*,Purodha Prasad, Vikram Wadhwa and Ishwar Singh

Maulana Azad Medical College, India

Submission: February 20, 2017; Published: June 16, 2017

*Corresponding author: Swati Tandon, Maulana Azad Medical College, Delhi, India, Tel:9891778593; Email:[email protected]

How to cite this article: Swati T. Submadibular Abscess with Velopharyngeal Insufficiency: Unusual Clinical Presentation of Tuberculosis. Int J Pul & Res Sci. 2017; 1(5): 555576. DOI:10.19080/IJOPRS.2017.02.555576

Abstract

Tuberculosis is a major public health problem in India. The rising incidence of multi drug resistant tuberculosis and unusual presentations of the disease is posing a great challenge for clinicians. We report an interesting case of 27 year old male who initially presented with submandibular abscess, subsequently developed velopharyngeal insufficiency during hospital stay and finally diagnosed as a case of extrapulmonary tuberculosis.

Introduction

Tuberculosis is one of the oldest diseases known to affect humans. There are two forms of tuberculosis: pulmonary and extrapulmonary. Extrapulmonary tuberculosis involves all sites other than lungs. Diagnosis of extrapulmonary tuberculosis is challenging as samples obtained from these sites may be paucibacillary, thus decreasing the sensitivity of diagnostic tests [1]. We report a case of unusual presentation of disseminated extrapulmonary tuberculosis, where patient initially presented as an acute submandibular abscess, then developed palatal perforation and later had massive pleural effusion. Pleural fluid analysis ultimately leads to the diagnosis of tuberculosis.

Case Report

A 27 year old male presented to ENT emergency of our hospital with diffuse swelling below the chin for 6 days. The swelling initially started as a furuncle which gradually progressed to involve the whole region below the chin. It was associated with pain and difficulty in eating. There was no breathing difficulty or fever. There was no history of trauma. There was no history of contact or past tuberculosis. On clinical examination, patient was thin built, cachexic and a febrile.

On local examination of neck, a diffuse 8x8cm swelling was seen in neck below the mandible extending from one angle of mandible to other. It was tender, skin overlying was erythematous and hyper pigmented, and temperature was raised. It was fluctuant and on aspiration pus was aspirated. A provisional diagnosis of acute submandibular abscess was made and incision and drainage was done with 10 ml drainage of pus. Floor of mouth was raised which subsided on drainage of abscess. Pus was sent for Gram staining, ZN staining (for TB) and culture sensitivity. Acid fast bacilli (AFB) were negative on ZN staining. On culture, pseudomonas was isolated and appropriate intravenous antibiotics were started according to sensitivity report. Hematological investigations including complete blood count, kidney function tests, liver function tests and urine routine microscopy was done, which were within normal limits. No immunodeficiency was detected. On second day, patient complained of nasal regurgitation and regurgitation of water through right ear. Voice of the patient also appeared hyper nasal. Nasal examination was unremarkable. On oropharyngeal examination, approx. 1cm ulcer with perforation was seen at the junction of the right anterior pillar and soft palate with pus on its margins. Patient denied any history of trauma or drug allergy. On examination of right ear, pus was seen filling the external auditory canal with non visualization of tympanic membrane. On cleaning the pus, slough was seen in antero-inferior wall of external auditory canal in the cartilaginous portion with pus coming through it. Tympanic membrane was found intact. Pus in the ear was thought to be due to spread of infection via the parotid space into the external auditory canal (EAC) via fissure of Santorini. Approx. 10-15ml pus drained from the submandibular incision site on second day. Patient was continued on i.v. antibiotics.

Nasogastric tube was inserted for feeding and biopsy was taken from the ulcer margins which showed chronic inflammation without any granulomas and was negative for acid fast bacilli. On third day, patient started complaining of purulent cough with mild respiratory difficulty. Chest physician opinion was sought who ordered chest x ray, montoux, sputum for AFB smear and started patient on tab. levofloxacin for 7days. On chest X ray, normal lung parenchyma with blunting of bilateral CP angles were seen indicating pleural effusion for which ultrasound guided pleural tap was done which revealed 4cm pleural thickness on right side and 5cm on left side. Montoux was 10mm, sputum for AFB was negative and ESR was raised (72mm/hr).

Analysis of pleural fluid revealed raised lymphocytic count raised LDH and ADA s/o tuberculosis. Thus, a diagnosis of extrapulmonary tuberculosis was made and patient was started on ATT. Initially, patient did not respond and respiratory distress worsened. Repeat chest x ray revealed massive pleural effusion for which chest drains were inserted bilaterally. 1000ml pus was drained from right side and 450ml from left side. Gradually patient started improving.

Chest drains were removed after 3 days. Submandibular wound also started healing and healthy granulation tissue was formed on 10th day. Anterior pillar perforation also healed by 10th day (Figure 1 & 2). Patient’s general condition improved and was discharged after 2 weeks on ATT. On follow up of 8weeks, patient is doing well and neck wound has healed.

The major pitfalls in the diagnosis of EPTB are atypical clinical presentations simulating other inflammatory conditions, resulting in delay of treatment. Therefore, a high index of suspicion is necessary to make an early diagnosis. In developing countries, the lack of diagnostic resources adds to the problems. In clinical practice, the cutaneous reaction to PPD commonly known as montoux test is used as an aid to diagnose TB but its value as a diagnostic tool is limited in adults in India, since about 40% of the adult population is infected with TB. In our case, montoux was 10mm suggestive of TB.

Smear examination for AFB, culture and histopathological examination remain as the classical diagnostic tests for TB. Laboratory diagnosis of TB is a tedious process because it depends on the growth of organisms. ZN staining for demonstration of acid fast bacilli on smears is a rapid method but it is less sensitive. In a study, ZN staining was compared with fluorescent (auramine rhodamine-AR) staining for demonstration of acid fast bacilli and it was observed that ZN staining showed 23.4% AFB smear positivity; 32.7% in sputum and 1.4% in extra-pulmonary specimens, whereas, Auramine Rhodamine staining showed 31.87% AFB smear positivity, 41.6% in sputa and 9.9% in extrapulmonary cases. The staining methods were also compared and evaluated against culture on LJ medium, (taken as ‘gold standard’): AR was 86.6% sensitive and ZN 67.3% sensitive [4].

Culture is the gold standard method but it’s major disadvantage is it is time consuming and takes 3 to8 weeks. The most recent advances have been development of molecular tools for amplifying DNA and RNA in clinical samples. A new nucleic acid amplification test called transcription mediated amplification has been developed [5]. These tests enable rapid identification of bacilli in few hours and are highly sensitive and specific. Also, since they involve amplification of bacilli DNA and RNA, they are very useful in paucibacillary specimens. Histopathological examination for mycobacterial lesions has also been described as a diagnostic tool. It has been found that microscopic examination of tissue sections frequently results in few or no bacilli seen, even if the lesions appear active histologically. This might be due to the effects of the fixative fluid and/or organic solvent, both of which are conventionally used to make tissue sections for histopathology, on the acid-fast staining of bacteria [6]. We also suspect the same in our case.

Measurement of adenosine deaminase (ADA) activity is one of the most widely used biomarkers in body fluids forthe diagnosis of EPTB. ADA is an enzyme involved in purin metabolism. Activity of this enzyme increases in TB patients because of the stimulation of T-cell lymphocytes by mycobacterial antigens. Detection of ADA in pleural fluid ultimately helped in establishing the diagnosis in our case.

TB of upper airway and oral cavity is usually secondary to pulmonary TB. Cases of primary oral TB have been described in literature [7]. On the other hand oral TB can be the first sign of pulmonary TB [8]. In our case, oral TB was one of the manifestations of extrapulmonary TB. Antituberculosis treatment is the mainstay in the management of EPTB.

Conclusion

Our case highlights the varied and unusual presentations of extrapulmonary tuberculosis. It also highlights the limitations of diagnostic tests routinely used for diagnosing TB. Extrapulmonary manifestation of TB can affect any part of body; therefore high clinical suspicion is needed to diagnose such cases early so as to prevent complications and spread of infection to others.