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A 67-year-old woman suffering from lupus with corticosteroids for 3 years, has repeatedly consulted for urinary signs: essentially recurrent cystitis. The time between onset of symptoms and diagnosis was 38 months. Gynecological examination (Figure 1) revealed adistal diverticulum palpable along the urethral path. The cytobacteriological examination of the urine had isolated an Escherichia coli resistant to the usual antibiotics. A vaginal diverticulectomy was performed in the gynecological position after antibiotic prophyl axis and loco- regional anesthesia (spinal anesthesia). The key to this surgery is the dissection of the diverticularcollar which will be closed to vicryl 4/0. The an atomopathological study of the piece has demonstrated the presence of a squamous metaplasia. The duration of stay was 5 days. No long-term complications were reported with a five-year follow-up. Repeated cystitis is often the prerogative of an organicanomaly. A good clinical examination is necessary. A systematic and untimely prescription of biological examinations and antibiotics without adequate clinical examination could promote and explain the emergence of many resistance to antibiotics.