Cancer Therapy and Oncology International Journal (CTOIJ)

Case Report

Hearing Loss Revealing A Squamous Cell Carcinoma Of External Auditory Canal In A PostIrradiated Patient For Nasopharyngeal Carcinoma: A Case Report

**B. Merzouqi, Zakaria Chafiki*, K. Salama, S. Rouadi, A. Abada, M. Roubal and M. Mahtar**

Hospital University, Morocco

Submission: February 21, 2017; Published: March 16, 2017

*Corresponding author: Zakaria Chafiki, Rue 266, Num 48, haymoulayabdellah, Casablanca, Hospital University, Morocco, Email: zakaria.Chafiki@gmail.com

How to cite this article: B Merzouqi, Zakaria C, K Salama, S Rouadi, A Abada,et al. Hearing Loss Revealing A Squamous Cell Carcinoma Of External Auditory Canal In A Post-Irradiated Patient For Nasopharyngeal Carcinoma: A Case Report. Canc Therapy & Oncol Int J. 2017; 3(5): 555621. DOI: 10.19080/CTOIJ.2017.03.555621

Abstract

Background: Primary Carcinoma of EAC is a rare disease accounting for less than 2% of head and neck cancers and has an annual incidence of around 1 per million populations. EAC carcinoma in post-irradiated nasopharyngeal carcinoma (NPC) patients occurs with an incidence of approximately 0.15%. It arises from the external ear and spreads to the temporal bone and surrounding sites. Although its rarity, it is a life threatening disease with practically a poor constant prognosis. Primary EAC carcinoma can occur with no specific symptoms. Aggressive surgery with postoperative radiation remain the usual treatment until now. We report a rare case of a squamous cell carcinoma (SCC) of EAC revealed by a progressive hearing loss as first presentation of the disease in a post-irradiated woman for NPC.

Results: a 47-year-old female with a past medical history of nasopharyngeal carcinoma treated with chemoradiation therapy, presented for repeated left-sided purulent ear discharge and progressive hearing loss. Otoscopic examination revealed a tissue mass filling the left EAC. CT scan revealed a soft tissue density process filling the EAC, encroaching upon the tympanic cavity and coming into contact with the handle of the malleus with no ossicular lysis nor EAC walls erosion. The biopsy of the mass was consistent with EAC SCC. The patient underwent lateral temporal bone resection with homolateral superficial parotidectomy and selective neck dissection and completed by an adjuvant external radiation therapy (RT).

Conclusion: Post-irradiation EAC SCC has similar symptoms and invades similar regions as its primary counterpart. This entity is usually discovered in the early stage in post-irradiated EAC SCC patients comparing to the primary EAC SCC. Aggressive surgical treatment is strongly recommended, but adjuvant radiotherapy for early stage EAC SCC should be provided cautiously to prevent further radiation induced complications.

Keywords: External Auditory Canal; Nasopharyngeal Carcinoma; Post-Irradiated Tumor; Squamous Cell Carcinoma; Temporal Bone Resection; Radiotherapy

Introduction

Primary Carcinoma of EAC (external auditory canal) is a quite rare disease accounting as a cause of 1 in 5000-15,000 ear complaints [1]. It represents less than 2% of head and neck cancers and has an annual incidence of around 1 per million populations [2,3]. It arises from the external ear and spreads to the temporal bone and surrounding sites. Periauricular soft tissues, parotid gland, temporomandibular joint and mastoid are the common sites of tumor progression. The carotid canal, jugular foramen, dura, middle and posterior cranial fossae are invaded in advanced stages [3,4]. Despite being extremely rare, EAC carcinoma is a life threatening tumor given its aggressive behavior. EAC carcinoma in post-irradiated NPC patients occurs with an incidence of approximately 0.15% [5], which is much higher than the incidence of primary EAC carcinoma among the general population. Many patients present with non-specific signs of chronic inflammation or infection which make detection and diagnosis of this malignant tumor difficult and the surgical management more challenging and risky [6]. The complex anatomicallocation and the susceptibility of tumor extension to contiguous tissues within a limited space make it complicated for surgery to achieve tumor-free margins [7]. Although several treatment modalities have been described in the literature, there is a lack of consensus as to the best treatment, mainly due to the absence of prospective randomized studies [8]. Aggressive surgery with postoperative radiation therapy [RT] remain the usual treatment so far [9]. In this study, we report a rare case of EAC SCC in a post irradiated female revealed by a hearing loss which makes it an unusual presentation of the disease.

Case Report

A 47-year-old Moroccan female with a past medical history of NPC [2009] treated with chemoradiation therapy, presented to the ENT department of University hospital of CASABLANCA for repeated left ear purulent discharge over the past 6 months and a progressive hearing loss. Otoscopic examination revealed a tissue mass filling the left EAC. Temporal bone CT scan revealed a soft tissue density filling the EAC [polyp], enhancing after injection of contrast product. The tissue process encroaches upon the tympanic cavity and comes into contact with the handle of the malleus with no detectable ossicular lysis nor EAC walls erosion (Figure 1). The biopsy of the mass was consistent with squamous cell carcinoma of the left EAC. The patient underwent lateral temporal bone resection with homolateral superficial parotidectomy and neck dissection. Anatomopathological examination of the specimen substantiated a well differentiated keratinizing and infiltrating squamous cell carcinoma of the left EAC. Resection margins were affected and parotid specimens were healthy. The surgical management was completed by adjuvant external radiotherapy. Immediately in postoperative check-up, the patient presented left peripheral facial palsy [House III] (Figure 2). One year follow-up, the patient lives with no signs of recurrence.

Discussion

Primary Carcinoma of EAC is a quite rare disease entity accounting as a cause of 1 in 5000-15,000 ear complaints [1]. It represents less than 2% of head and neck cancers and has an annual incidence of around 1 per million populations [2,3]. Squamous cell carcinoma [SCC] constitutes 82% of the tumors involving the auditory canal, middle ear, and mastoid [10] while adenoid cystic carcinoma [ACC] is seen only in 6-10% of all cases [11]. Chronic suppurative otitis media and previous irradiation are thought of as etiological factors [12]. This tumor usually occurs in the 5th-7th decade of life [13,14] with a slight male preponderance. Primary EAC carcinoma shows no specific symptoms, besides, they are occult during the early stage, which makes early diagnosis very difficult with otorrhea [50-90%] being the most common reported symptom in various series followed by pain, hearing loss and mass the auditory canal [11]. Facial nerve palsy at presentation has been reported variably indifferent series in 16-50% of patients [15]. This tumor has always had a very poor prognosis given its aggressive nature and the susceptibility to spread along vascular and neural pathways [16]. The main cause of death is, usually, aggressive local recurrence [17].

The post-irradiated EAC carcinoma has been infrequently reported [18-25]. Lo et al. [5] reported that the incidence of EAC carcinoma in the post-irradiated NPC population was 1000 times greater than the reported incidence of primary EAC carcinoma in the general population. The post-irradiated EAC SCC shows no special symptoms compared with its primary counterpart. Our patient complained of a progressive hearing loss with a repeated purulent ear discharging over 6 months with a latency period of 6 years from the first cure of RT which is much lower than the period reported in others studies [5,25].

Jing Wang et al. [25] reported in his study including 9 irradiated NPC patients among a total of 50 patients, that the proportion of early stage cases in the post-irradiated EAC SCC patients was higher than that in the primary EAC SCC patients. He explained that by the nonspecific symptomatology of the early stage of EACSCC so that early diagnosis of primary EACSCC is difficult to achieve and the fact that post-irradiated patients are more aware of lesions in their radiation field so they may seek evaluation by physicians as soon as possible. Furthermore, the NPC patients presented with more symptoms at initial presentation than did the primary EAC SCC patients which makes it another likely reason so as the NPC patients were diagnosed earlier than the primary EAC SCC patients.

Since it is a rare malignancy, there is no established American Joint Committee on Cancer [AJCC] or Union for International Cancer Control [UICC] staging system for this type of neoplasm so far. Arriaga et al. [26] suggested a staging system in 1990, which has since entered the literature as the Pittsburgh staging system, allowing for a more accurate comparison of treatment and outcomes in patients with this disease. This system underwent minor revision by Moody et al. [2] in 2000. The latter combines the histopathological and radiological findings, leading to a more comprehensive staging of these tumors.

Although several treatment modalities have been described in the literature, there is a lack of consensus as to the best treatment, mainly due to the absence of prospective randomized studies [8].Surgical resection is crucial as a treatment modality, and early surgical intervention is associated with increased survival [2,9,27].

The management of these tumors was initially described by Politzer [28] in 1883. Since then, the management has evolved from piecemeal temporal bone resection to en bloc temporal bone resection and further to combined modality treatment of surgery and post-operative radiation therapy [RT] [9]. In a retrospective analysis of 21 patients, Kollert et al. [29] found that stage- dependent lateral or subtotal TBR combined with parotidectomy as well as a neck dissection was the most beneficial approach.

While some investigators suggest RT for recurrent cases, questionable free margins and/or lymph node metastases [29], most of authors recommend postoperative RT for T3 or T4 tumors in combination with extended temporal bone resection [30,31] and some of them recommend RT systematically to T1 or T2 tumors in adjunct to surgery [32,33]. A retrospective review including 144 patients did not find evidence of improved survival with the addition of RT to TBR [with 48 vs. 44.4% 5-year survival for TBR + RT vs. TBR alone, respectively] [34]. Jing Wang [25] reported that Adjuvant postoperative RT was not significantly correlated with the overall survival rates but it is unnecessary for early stage EAC SCC, particularly in patients with guaranteed intraoperative tumor-free margins. Our patient has undergone a postoperative RT given the affected resection margins despite the extensive surgical treatment that was performed.

Surgery or radiotherapy alone is usually used for T1 lesion. Ogawa et al. [14] found the 5-year DFS rate in T1, T2 and T3 patients to be 83, 45 and 0% in the RT group [P<0.0001] and 75, 75 and 46% in the group that underwent surgery with RT [P=0.13]. Based on those results, they recommend radical radiotherapy alone as the treatment of choice for early-stage [T1] disease and surgery with radiotherapy for more advanced [T2-3] disease.

According to Jing Wang [25], the post irradiated EAC SCC patients had received RT for NPC previously, and adjuvant postoperative RT may induce serious complications even over the long term after the first radiotherapy. In his study, 5/9 postirradiated EAC SCC patients received another course of adjuvant RT and three of them developed severe radionecrosis. The high incidence of radiation-induced necrosis in the irradiated EAC SCC patients imposes caution when applying postoperative radiation particularly when it comes to patients with early- stage carcinoma. Accordingly, it is unnecessary to administer adjuvant radiotherapy to patients with early-stage EAC SCC with guaranteed tumor-free margins.

There is conflicting data in the literature regarding the benefits of chemotherapy with or without radiation. While Ogawa et al. [14] did not find chemotherapy to increase disease free survival in any stage of the disease, a multi-institutional review by Yin et al. [13] has suggested increased survival with chemotherapy in stage 3 and 4 disease, if combined with surgery and radiation [28.7 vs. 52.5%; surgery + radiation vs. surgery + radiation + chemotherapy].

A number of factors other than the tumors stage, poorly differentiated tumors, [35] lymph node involvement, and facial nerve palsy [36] have been noted to confer poor prognosis. Possible predisposing factors for the disease are preceding head and neck radiation for nasopharyngeal and skin neoplasms [36].

Conclusion

Post-irradiation EAC SCC has similar symptoms and invades similar regions as its primary counterpart. This entity is usually discovered in the early stage in post-irradiated EAC SCC patients comparing to the primary EAC SCC. Aggressive surgical treatment is strongly recommended, but adjuvant radiotherapy for early stage EAC SCC should be provided cautiously to prevent further radiation induced complications.