Results Parameters

L+A(n=16 wk 24 ,n=15 wk 48)

T(n=16)

E(n=16 )

P value

C T P score ≥2 decrease

At week 24

3(20%)s

6(37.5%)

7(43.8%)

0.181

At week 48

6(40%)

7(43.8%)

10(62.5%)

0.133

CTP score- change in CTP

At week 24

0.69 ±o.94

1.50 ±1.673

1.56±1.153

0.116

At week 48

1.33 ±1.05

1.94±1.57

2.00±1.37

0.326

Decrease in MELD score

At week 24

1.4 ±3.36

2.0±3.25

2.4±1.82

0.620

At week 48

1.7 ±2.36

2.4±3.89

2.7±1.87

0.611

Change in serum HBV DNA (median log decrease)

At week 24

2.60 ±1.35

3.06±1.88

2.69±1.35

0.674

At week 48

3.73 ±1.39

3.94±1.88

3.31±1.82

0.577

HBV DNA undetectable (%)

At week 24

8(48%)

8 (50%)

10(60%)

0.717

At week 48

10 (67%)

10(62%)

12(75%)

0.815

Serological Response

HBeAg loss

At week 48

2(50%))(n=4)

2(50%)(n=4)

2((66%)(n=3)

0.885