The Enhanced Role of Diet in Crohn's Disease

The Hruska Postulate identifies Crohn’s disease (CD) as the consequence of two inter-related actions involving Mycobacterium avium subspecies para tuberculosis (MAP). The potential for CD is created when a newborn, lacking effective acquired immunity, has to deal with infection by MAP. The consequence of arresting MAP replication results in fixation of the pro-inflammatory cytokine response to MAP and the loss of immunological tolerance. The clinical manifestation of CD is contingent upon repeat MAP antigen challenges and the elicited cytokine responses that, in time, overwhelm the regenerative capacity of the lining gastrointestinal mucosa [1,2].

The genesis of dietary intervention in CD is not new. Without understanding the events that combined to produce disease, Crohn's afflicted individuals had previously identified individual foods that exacerbated their symptoms. This information became integrated into what are termed dietary intervention regimens.
Crohn's disease exclusion diets evolved primarily from small nonrandomized clinical trials. Chiba reported that 94% of Crohn's afflicted individuals who remain on a semi-vegetarian diet maintained in clinical remission whereas 33% of individuals who returned to a regular diet relapsed [3]. Sigall-Boneh reported that 70% of Crohn's afflicted individuals achieved clinical remissions on a Crohn's disease exclusion diet. What was impressive in his data was the number of individuals who achieved normalization of their C-reactive levels [4].
Identifying MAP as the trigger antigen of an immune-mediated disease allows construction of CD exclusion diets whose therapeutic potential can be augmented by specific nutritional supplementation to convert temporary remissions to permanently sustained remissions [5].
An unintended experiment documented that stress reduction and target nutrition resulted in total eradication of MAP massive infection in a cow (Johne's disease) that should have been terminal [6]. The advertent result was total destruction of MAP and reversal of gross and histologic evidence of disease. The cellular marker left in place identified the mechanism by which the immune system destroys MAP. Previously, Johne's disease had been deemed incurable. That dietary supplementations that targeted enhancement of cell-mediated immunity, coupled with stress reduction, could empower the immune system to, not suppress replication, but actually destroy MAP brought into focus the potential of immune enhancing dietary intervention to expand its conceptual role from an adjunctive to a therapeutic modality.
Once an individual experiences diarrhea for a sustained period of time, his or her immune system becomes progressively compromised. In Crohn's disease, the mucosal tissue destruction and inflammatory infiltration of the lamina propria constitute impediments to absorption of substances from the gastrointestinal tract. Semi-vegetarian diets and the IDI immunotherapeutic formulation for Johne's disease share a number of key elements that are necessary for optimal immune system function. Some of these elements, zinc, selenium, Vitamins C, D, and E, are reduced in chronic diarrheal diseases.

Zinc
Crohn's disease results in decreased zinc absorption and increased exogenous loss [7,8].The body has no specialized system to store zinc. Individuals with Crohn's disease have zinc deficiency impairment affecting a broad spectrum of mechanisms involved in the killing of intra-cellular pathogens [9,10]. Interlukin-1 (IL-1) tumor necrosis factor (TNF) and interlukin-6 (IL-6) cause a marked decrease in serum zinc concentration [11,12]. Among the major functional consequences of zinc deficiency are anorexia, diarrhea, and impaired immunological responsiveness.

Selenium
Selenium is an essential component of selenocyteine proteins within the immune system. Selenium dependent glutathione peroxidases protect neutrophils from oxygen-derived radicals and act as an anti-oxidase in the extra-cellular space [13]. Vitamin E deficiency is frequently concomitantly present in selenium deficient animals [14]. Deficiency of selenium undermines the integrity of the gastrointestinal mucosa by facilitating the action of proinflammatory compounds.

Vitamin D
Vitamin D3's active form plays an important role in cell differentiation and proliferation of the immune system. It suppresses cell proliferation that results in a shift from a TH1 to TH2 response, skews T cell maturation away from TH17, and inhibits monocyte production of pro-inflammatory cytokines IL-1, IL-6, IL-8 IL-12 and TNF alpha [15,16]. In Crohn's disease,symptom amelioration to actual transient remission has been observed following aggressive vitamin D supplementation.

Vitamins C & E:
Vitamin C regenerates vitamin E from its oxidized form. The lipid soluble antioxidant vitamin E not only protects the integrity of cell membranes, but functions synergistically with other nutritional elements that beneficially influence cell-mediated immunity [17][18][19]. The salvage of vitamin E influences the immune functions of selenium which in turn has a beneficial impact on copper and zinc utilization. The body has no specialized system to store Vitamin C.
The dietary therapeutic objectives in CD are:

A.
Elimination of all foods potentially adulterated by MAP.

B.
Restoration of an anabolic metabolism in Crohn's afflicted individuals.

C.
Utilization of targeted dietary supplementation to enhance cellular immunity.
Given the ability to affect MAP, Immune system targeted dietary supplementation stands to be a powerful co-therapy with antimicrobials in destroying the template that sustains the body's dysfunctional pro-inflammatory response to the antigens of MAP.