Table 2: Table 2: Cycle AMP accumulation induced by β1 IgG and ISO in rat isolated atria.
Values are mean ± SEM of six experiments in each case performed by duplicate. * P< 0.001 β1 IgG and ISO vs. Basal; ** P< 0.001 β1 IgG and ISO in hypoxia vs. in normoxia.

Additions

Normoxia
(cAMP pmol/ml)

Hypoxia
(cAMP pmol/ml)

Basal

0.8 ± 0.02

0.7 ± 0.01

ISO (1x10-7 M)

2.2 ± 0.18*

1.7 ± 0.11*

ISO + atenolol (1x10-7 M)

0.7 ± 0.05

0.9 ± 0.03

β1 IgG (1x10-8 M)

2.2 ± 0.31*

1.4 ± 0.09*

β1 IgG + atenolol (1x10-7 M)

0.6 ± 0.02

0.6 ± 0.05

β1 IgG + β1 synthetic peptide (5x10-5 M)

0.9 ± 0.08

0.58 ± 0.04

Normal IgG (1x10-8 M)

1.1 ± 0.09

0.61 ± 0.05