Table 2: Table 2: Cycle AMP accumulation induced by β1 IgG and ISO in rat isolated atria. Values are mean ± SEM of six experiments in each case performed by duplicate. * P< 0.001 β1 IgG and ISO vs. Basal; ** P< 0.001 β1 IgG and ISO in hypoxia vs. in normoxia. |
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Additions |
Normoxia |
Hypoxia |
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Basal |
0.8 ± 0.02 |
0.7 ± 0.01 |
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ISO (1x10-7 M) |
2.2 ± 0.18* |
1.7 ± 0.11* |
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ISO + atenolol (1x10-7 M) |
0.7 ± 0.05 |
0.9 ± 0.03 |
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β1 IgG (1x10-8 M) |
2.2 ± 0.31* |
1.4 ± 0.09* |
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β1 IgG + atenolol (1x10-7 M) |
0.6 ± 0.02 |
0.6 ± 0.05 |
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β1 IgG + β1 synthetic peptide (5x10-5 M) |
0.9 ± 0.08 |
0.58 ± 0.04 |
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Normal IgG (1x10-8 M) |
1.1 ± 0.09 |
0.61 ± 0.05 |