Table 1: Influence of ISO and normal IgG atria on prostaglandins production in rat isolated atria. Values are mean ± SEM of six experiments in each case performed by duplicate. * P< 0.001 ISO vs. Basal; ** P< 0.01 ISO vs. ISO + atenolol. | ||||
ADDITIONS |
Concentration of Prostaglandins (ng/ml) |
|||
Normoxia |
Hypoxia |
|||
PGE2 |
6-Keto- PGF1α |
PGE2 |
6-Keto- PGF1α |
|
Basal |
4.7± 0.3 |
5.1± 0.4 |
5.8 ± 0.5 |
5.9 ± 0.5 |
ISO (1x10-7 M) |
9.7± 0.6* |
16.7± 1.3* |
14.6 ± 1.3* |
16.9± 1.5* |
ISO + atenolol (1x10-7 M) |
3.8 ± 0.4** |
5.7± 0.6** |
7.3 ± 0.6** |
5.4± 0.5** |
Normal IgG (1x10-8 M) |
4.8 ± 0.4 |
5.3± 0.7 |
5.9 ± 0.6 |
5.9± 0.7 |