Table 1: Influence of ISO and normal IgG atria on prostaglandins production in rat isolated atria. Values are mean ± SEM of six experiments in each case performed by duplicate. * P< 0.001 ISO vs. Basal; ** P< 0.01 ISO vs. ISO + atenolol.

 ADDITIONS

Concentration of Prostaglandins (ng/ml)

Normoxia

Hypoxia

PGE2

6-Keto- PGF

PGE2

6-Keto- PGF

Basal

4.7± 0.3

5.1± 0.4

5.8 ± 0.5

5.9 ± 0.5

ISO (1x10-7 M)

9.7± 0.6*

16.7± 1.3*

14.6 ± 1.3*

16.9± 1.5*

ISO + atenolol (1x10-7 M)

3.8 ± 0.4**

5.7± 0.6**

7.3 ± 0.6**

5.4± 0.5**

Normal IgG (1x10-8 M)

4.8 ± 0.4

5.3± 0.7

5.9 ± 0.6

5.9± 0.7